49633-80-9

Upstream product

• 88327-64-4 2,3-dioxo-1,4-diazabicyclo<4.5.0>undecane 
• 42839-32-7 2-aminomethyl-2,3,4,5,6,7-hexahydro-1H-azepine 
• 13414-33-0 7-ethoxy-3,4,5,6-tetrahydro-2H-azepine 
• 64480-12-2 2-nitromethylene-2,3,4,5,6,7-hexahydro-1H-azepine 

Downstream Products

• 80276-18-2 (4-Amino-phenyl)-(octahydro-pyrazino[1,2-a]azepin-2-yl)-methanone 
• 60390-52-5 1-(4-Fluoro-phenyl)-4-(octahydro-pyrazino[1,2-a]azepin-2-yl)-butan-1-one 
• 88327-79-1 4-(2-phenylethyl)-1,4-diazabicyclo<4.5.0>undecane 
• 88327-81-5 1-(Octahydro-pyrazino[1,2-a]azepin-2-yl)-3-phenoxy-propan-2-ol 

Relevant academic research and scientific papers

Studies in Potential Filaricides: Part XIII - Synthesis of 1,4-Diazabicyclononanes, 1,4-Diazabicyclodecanes and 1,4-Diazabicycloundecanes as diethylcarbamazine Analogs

1,4-Diazabicyclononanes (13 - 20), 1,4-diazabicyclodecanes (21 - 28), 1,4-diazabicycloundecanes (29 - 34), 1,4-diazabicyclononan-5-ones (37 - 41) and 1,4-diazabicyclodecan-5-ones (42 - 44) having alkyl and acyl substituents at 4-position have been synthesized and evaluated for their filaricidal activity against Litomasoides carinii infection in cotton rats.Except 4-diethylcarbamoyl-1,4-diazabicyclononane (13), which exhibits significant activity, being about 3/5th as active as the standard diethylcarbamazine (DEC), none of the other compounds shows any activity against adult worms.The results have been rationalised in terms of critical bulk around the N-1 of the piperazine ring of DEC.From this work and earlier published results it appears that both axial and equatorial N-CH3 bonds in DEC are acceptable for activity.