49656-91-9

Usage

Uses

Used in Pharmaceutical Industry:
(4,5-DIPHENYL-4H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID HYDRAZIDE is used as a bioactive molecule for its antimicrobial and antifungal properties, making it a potential candidate for the development of new drugs to combat resistant infections.
Used in Agricultural Industry:
In agriculture, (4,5-DIPHENYL-4H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID HYDRAZIDE is used as a bioactive agent for its potential to control microbial and fungal infections in crops, thereby enhancing crop health and yield.
Used as a Chelating Agent:
(4,5-DIPHENYL-4H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID HYDRAZIDE is utilized as a chelating agent in various chemical processes, where its ability to bind with metal ions can be beneficial for applications such as water treatment or the synthesis of metal-organic frameworks.
Used as a Precursor in Organic Synthesis:
(4,5-DIPHENYL-4H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID HYDRAZIDE serves as a precursor in the synthesis of other organic compounds, leveraging its unique structure to form new molecules with potential applications in various fields, including materials science and medicinal chemistry.

InChI:InChI=1/C16H15N5OS/c17-18-14(22)11-23-16-20-19-15(12-7-3-1-4-8-12)21(16)13-9-5-2-6-10-13/h1-10H,11,17H2,(H,18,22)

Upstream product

• 91759-70-5 ethyl 2-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 
• 103-72-0 phenyl isothiocyanate 
• 613-94-5 benzoic acid hydrazide 
• 6596-82-3 4,5-diphenyl-4H-1,2,4-triazole-3-thiol 
• 6596-82-3 4,5-diphenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 1768-59-8 1,4-diphenylthiosemicarbazide 
• 13153-01-0 1-benzoyl-4-phenyl-3-thiosemicarbazide 

Downstream Products

• 93300-42-6 2-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(4-methylphenyl)methylidene]acetohydrazide 
• 93300-45-9 (4,5-Diphenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(4-chloro-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 93300-43-7 2-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(4-methoxyphenyl)methylidene]acetohydrazide 
• 93300-41-5 2-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-hydroxyphenyl)methylidene]acetohydrazide 
• 58360-47-7 5-[(4,5-diphenyl-4H-1,2,4-triazol-3-ylthio)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 93300-36-8 5-(4,5-Diphenyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-4-methyl-4H-[1,2,4]triazole-3-thiol 
• 93300-37-9 5-(4,5-Diphenyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-4-naphthalen-1-yl-4H-[1,2,4]triazole-3-thiol 
• 1415559-07-7 4-ethyl-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 58360-48-8 4-allyl-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 537016-49-2 4-cyclohexyl-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 58360-47-7 4-phenyl-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 449782-42-7 4-(4-bromophenyl)-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1400271-85-3 4-(4-chlorophenyl)-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 537016-53-8 4-(4-methoxyphenyl)-5-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 

Relevant academic research and scientific papers

Synthesis and characterisation of some coumarin-1,2,4-triazol-3-thioether hybrid molecules

A new series of N′-{[(4-methyl/phenyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetyl}-2-oxo-2H-chromene-3-carbohydrazides was synthesised via the reaction of 2-[(4-methyl/phenyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetohydrazides and 3-(1H-benzotriazol-1-ylcarbonyl)-2H-chromen-2-ones in good yields.

Alkylation of 1,2,4-triazole-3-thiols with haloalkanoic acid esters

Alkylation of 4,5-disubstituted 4H-1,2,4-triazole-3-thiols with methyl chloroformate and ethyl chloroacetate chemoselectively afforded the corresponding S-alkyl derivatives, whereas the alkylation of 5-benzyl-4-phenyl-4H-1,2,4-triazole-3-thiol with methyl 3-bromopropanoate gave an inseparable mixture of S- and N-alkylation products. Hydrazinolysis of S-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl) methyl carbonothioate involved anomalous cleavage with formation of the initial 4,5-disubstituted 1,2,4-triazole and methyl hydrazinecarboxylate.

Synthesis and Antimicrobial Evaluation of New Schiff Base Hydrazones Bearing 1,2,4-Triazole Moiety

This study presents the synthesis and spectral analysis of new Schiff base hydrazone derivatives. New compounds were prepared by the reaction of [(4-phenyl-5-substituted-4H-1,2,4-triazol-3-yl)sulfanyl] acetohydrazide with various aldehydes. The structures

Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives

This study presents the synthesis and spectral analysis of new derivatives of 1,2,4-triazole-3-thione and 1,3,4-thiadiazole. New compounds were prepared by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antibacterial activity by using the agar dilution technique. Six of the compounds had potential activity against Gram-positive bacteria (minimal inhibitory concentration [MIC] = 15.63-500 μg/mL). Some compounds showed good activity especially against Bacillus subtilis ATCC 6633 (MIC = 15.63-250 μg/mL), Staphylococcus aureus ATCC 25923 (MIC = 31.25-250 μg/mL), and Micrococcus luteus ATCC 10240 (MIC = 125-250 μg/mL).

Synthesis, in vitro cytotoxicity, and antibacterial studies of new asymmetric bis-1,2,4-triazoles

A series of asymmetric bis-1,2,4-triazoles (4a-l) were synthesized from respective 1,2,4-triazole-3-thiocarbohydrazides (2a, b) via base catalyzed dehydrative cyclization of thiosemicarbazide intermediates (3a-l). The synthesized compounds were characteri

Syntheses of Substituted 3-Mercapto-1,2,4-triazoles as Potential Antimicrobial Agents

Some hydrazides (3-5) and amides (6-17) have been prepared by reacting 3,4-disubstituted ethyl 1,2,4-triazole-5-mercaptoacetates (1,2) with hydrazines and alkylamines respectively.Treatment of the hydrazides (3,4) with alkyl or aryl isothiocyanates afford