58360-47-7

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 49656-91-9 2-[(4-phenyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetohydrazide 
• 58360-45-5 4-phenyl-1-{[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1768-59-8 1,4-diphenylthiosemicarbazide 
• 91759-70-5 ethyl 2-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 
• 6596-82-3 4,5-diphenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 6596-82-3 4,5-diphenyl-4H-1,2,4-triazole-3-thiol 
• 613-94-5 benzoic acid hydrazide 

Relevant academic research and scientific papers

Synthesis, in vitro cytotoxicity, and antibacterial studies of new asymmetric bis-1,2,4-triazoles

A series of asymmetric bis-1,2,4-triazoles (4a-l) were synthesized from respective 1,2,4-triazole-3-thiocarbohydrazides (2a, b) via base catalyzed dehydrative cyclization of thiosemicarbazide intermediates (3a-l). The synthesized compounds were characteri

Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives

This study presents the synthesis and spectral analysis of new derivatives of 1,2,4-triazole-3-thione and 1,3,4-thiadiazole. New compounds were prepared by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antibacterial activity by using the agar dilution technique. Six of the compounds had potential activity against Gram-positive bacteria (minimal inhibitory concentration [MIC] = 15.63-500 μg/mL). Some compounds showed good activity especially against Bacillus subtilis ATCC 6633 (MIC = 15.63-250 μg/mL), Staphylococcus aureus ATCC 25923 (MIC = 31.25-250 μg/mL), and Micrococcus luteus ATCC 10240 (MIC = 125-250 μg/mL).

Syntheses of Substituted 3-Mercapto-1,2,4-triazoles as Potential Antimicrobial Agents

Some hydrazides (3-5) and amides (6-17) have been prepared by reacting 3,4-disubstituted ethyl 1,2,4-triazole-5-mercaptoacetates (1,2) with hydrazines and alkylamines respectively.Treatment of the hydrazides (3,4) with alkyl or aryl isothiocyanates afford