49656-93-1

Upstream product

• 21358-13-4 2-[3-phenoxymethyl-4-phenyl-1,2,4-triazole]-5-thiol 
• 131142-17-1 ethyl [3-phenoxymethyl-4-phenyl-1,2,4-triazole-5-yl-thio]acetate 

Downstream Products

• 131943-04-9 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(4-chloro-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 131943-05-0 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(4-nitro-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 131942-72-8 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 131943-09-4 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 131943-08-3 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(2-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 1255533-34-6 (E)-2-[(3-phenoxymethyl-4-phenyl-1,2,4-triazole-5-yl-thio)acetyl]-4-nitrobenzylidenehydrazine 
• 1255533-36-8 (E)-2-[(3-phenoxymethyl-4-phenyl-1,2,4-triazole-5-yl-thio)acetyl]-4-methoxybenzylidenehydrazine 
• 1255533-38-0 (E)-2-[(3-phenoxymethyl-4-phenyl-1,2,4-triazole-5-yl-thio)acetyl]-4-N,N-dimethylaminobenzylidenehydrazine 
• 131943-06-1 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 131943-07-2 (5-Phenoxymethyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid [1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 

Relevant academic research and scientific papers

Synthesis, crystal structure and biological activity of novel N-2-chlorophenyl-N′-2-[3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio]acetyl Hydrazone

N-2-Chlorophenyl-N′-2-[3-phenoxymethyl-4-phenyl[1,2,4]triazole-5-thio]acetyl hydrazone was synthesized by condensation reaction of 2-[3-phenoxymethyl-4-phenyl[1,2,4]triazole-5-thio]acethydrazide with 2-chlorobenzaldehyde under the conditions of microwave

Microwave-induced synthesis and bioactivity of [3-Phenoxy-methyl-4-phenyl- 1,2,4-triazole-5-yl-thio]acetyl hydrazone derivatives

A convenient method for the preparation of hydrazone derivatives from condensation reaction of [3-phenoxymethyl-4-phenyl-1,2,4-triazole-5-yl-thio] acetyl hydrazine with various substituted benzaldehydes under conditions of microwave irradiation has been developed. This method has many merits including high yields, short reaction times, ease of work-up, and simple operation. All of the compounds have been characterized by 1H NMR, 13C NMR, IR spectra and elemental analysis. In addition, the preliminary biological activity tests showed that some of the title compounds remarkably enhanced the root elongation of rape seedings; moreover, some compounds possessed antibacterial activity against Bacillus subtilis. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

SYNTHESIS OF SOME NEW 3-ARYLOXYMETHYL-4-PHENYL-5-(N-SUBSTITUTED CARBOXYAMIDOMETHYL THIO)-s-TRIAZOLES

3-Aryloxymethyl-4-phenyl-5-mercapto-s-triazoles (1a-c) have been synthesized and reacted with N-chloroacetyl derivatives of aromatic and/or heterocyclic amines to yield 5-(N-aryl/heterocyclyl)-carboxamidomethyl thio-s-triazole derivatives 2a-u and 3a-i respectively.Reaction of 1a-c with ethyl chloroacetate gave the corresponding esters 4a-c which were reacted with hydrazine hydrate to give hydrazides 5a-c.Condensation of 5a-c with aromatic aldehydes gave Schiff's bases 6a-u which on cycloaddition reaction with thioglycolic acid yielded 4-thiazolidinones 7a-g.Some of these compounds were screened in vitro for their antibacterial activities.