49661-00-9Relevant academic research and scientific papers
Visible-light-promoted α-methoxymethylation and aminomethylation of ketones with methanol as the C1 source
Yang, Jingya,Liu, Cai,Zhou, Hongyan,Fan, Rundong,Ma, Ben,Li, Zheng
supporting information, p. 5572 - 5576 (2021/07/02)
Visible-light-promoted α-methoxymethylation and aminomethylation of ketones using methanol as a sustainable C1 source have been developed. With rose bengal as the photosensitizer and air as the green oxidant, the methoxymethylation reactions proceeded smoothly under visible light irradiation at ambient temperature. Additionally, a one-pot one-step α-aminomethylation of ketones was achieved by adding N-nucleophiles. Preliminary mechanism studies suggest that the reaction mainly proceedsviaa radical pathway.
Cobalt-Catalyzed α-Methoxymethylation and Aminomethylation of Ketones with Methanol as a C1 Source
Yang, Jingya,Chen, Shuwen,Zhou, Hongyan,Wu, Chengqi,Ma, Ben,Xiao, Jianliang
supporting information, p. 6774 - 6779 (2018/10/25)
Using methanol as a sustainable C1 source, cobalt-catalyzed α-methoxymethylation and α-aminomethylation of ketones have been developed. With cheap CoCl2·6H2O as catalyst and TBHP as oxidant, the methoxymethylated products were obtained within a short reaction time in up to 91% yield. Based on the observed reversibility of methoxy adduct to enone, the α-aminomethylation of ketones was then achieved by a one-pot methylenation/aza-Michael addition sequence. In addition, an easy way to convert α-methoxymethyl ketones to α-aminomethyl ketones has been discovered.
Inotropic, vasodilator and low Km, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) inhibitory activities of 4a-methyl-4,4a-dihydro-5H-indenopyridazin-3(2H)-ones and 4a-methyl-4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-ones
Bakewell, S J,Coates, W J,Comer, M B,Reeves, M L,Warrington, B H
, p. 765 - 774 (2007/10/02)
Novel 7-substituted-4,4a-dihydro-4a-methyl-5H-indenopyridazin-3-ones and 8-substituted-4a-methyl-benzocinnolin-3-ones have been synthesized and their PDE III inhibitory, inotropic and vasodilator potencies compared with those of their normethyl analogues and their bicyclic 4,5-dihydro-6-phenylpyridazinone analogues.The structure-activity relationships of the tricyclic pyridazinones differ from those of bicyclic pyridazinones mainly in respect of the effect of introducing the methyl group into the pyridazinone ring.Whilst in the4,5-dihydro-6-phenylpyridazin-3(2H)-ones, introduction of a 5-methyl group has been widely reported to lead to compounds of significantly greater potency, the novel tricyclic 4a-methylpyridazinones showed similar levels of inotropic, vasodilator and PDE III inhibitory potency to their normethyl analogues.Possible reasons for this difference in behaviour are discussed.
