49672-05-1

Usage

Uses

Used in Pharmaceutical Research and Development:
Methyl 2-(1H-benzoimidazol-2-yl)acetate is utilized as a key intermediate in the synthesis of new pharmaceutical drugs due to its ability to interact with biological systems and exhibit specific biological activities. Its unique structure and properties make it a promising candidate for the development of innovative therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, methyl 2-(1H-benzoimidazol-2-yl)acetate serves as a versatile building block for the creation of various organic compounds. Its reactivity and stability contribute to its suitability in a wide range of synthetic processes, facilitating the production of diverse chemical entities.
Used in Chemical Industry:
Methyl 2-(1H-benzoimidazol-2-yl)acetate is employed in the chemical industry for its stability and reactivity, making it a valuable component in the synthesis of various chemical products. Its application in this industry underscores its versatility and potential for use in multiple sectors.

InChI:InChI=1/C10H10N2O2/c1-14-10(13)6-9-11-7-4-2-3-5-8(7)12-9/h2-5H,6H2,1H3,(H,11,12)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 67-56-1 methanol 
• 13570-08-6 (1H-benzimidazol-2-yl)acetic acid 
• 4857-04-9 2-chloromethyl-1H-benzimidazole 
• 201230-82-2 carbon monoxide 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 

Relevant academic research and scientific papers

A new route to pyrimido [1,6-a] benzimidazoles : Reactivity of activated 2-benzimidazoles with N-Acyl imidates as β-dielectrophiles under microwave irradiation

Activated 2-benzimidazoles react with a variety of N-Acyl imidates under microwave irradiation in open vessels to give the corresponding pyrimido [1,6-a] benzimidazoles.

NOVEL FERROPORTIN INHIBITORS

The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.

Synthesis of β-enamino acid and heteroaryl acetic acid derivatives by Pd-catalyzed carbonylation of α-chloroimines and 2-chloromethyl aza-heterocycles

β-Enamino esters or amides can be synthesized in a single step by a carbonylative coupling of α-chloroimines with alcohols or amines under Pd-catalysis. The methodology has been also applied to the preparation of heteroaryl acetic acid derivatives starting from chloromethyl heteroaromatic rings containing a C-N double bond. The in situ generation of a β-imino acylpalladium species has been proposed as a key step for the process.

New synthesis of 2-benzimidazoleacetates and study of their Knoevenagel reaction

To obtain 2-benzimidazolyl acrylate 2, a new efficient synthesis of 2-benzimidazoleacetate, involving esterification of 2-benzimidazole acetic acid at low temperature as the crucial step, was developed. The generality and efficiency of the process was illustrated by the high-yield synthesis of methyl, ethyl, i-propyl, and n-butyl 2-benzimidazoleacetate. The Knoevenagel reaction of 2-benzimidazoleacetate with aromatic aldehydes was studied. It was found that only in the presence of a catalytic amount of morpholine could the Knoevenagel reaction proceed to give the expected 3-aryl-2-benzimidazolyl acrylate. A mechanism for the morpholinecatalyzed reaction is suggested. Springer Science+Business Media B.V. 2011.