49674-15-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-5-nitrobenzonitrile is used as a synthetic intermediate for the production of various pharmaceuticals, leveraging its reactivity to form the backbone of multiple medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-5-nitrobenzonitrile is utilized as a precursor in the synthesis of different agrochemicals, contributing to the development of products designed to protect crops and enhance agricultural yields.
Used in Dye Industry:
3-Bromo-5-nitrobenzonitrile is employed as a chemical intermediate in the dye industry, playing a role in the creation of diverse dyes used across various applications.
Used in Organic Synthesis:
3-Bromo-5-nitrobenzonitrile is used as a versatile building block in organic synthesis, serving as a key component in the preparation of biologically active molecules for research and development purposes.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-Bromo-5-nitrobenzonitrile is applied as a reactive intermediate that facilitates the exploration of new chemical space and the development of potential therapeutic agents.

InChI:InChI=1/C7H3BrN2O2/c8-6-1-5(4-9)2-7(3-6)10(11)12/h1-3H

Upstream product

• 51339-40-3 3-bromo-5-nitrobenzoyl chloride 
• 54321-80-1 3-bromo-5-nitrobenzamide 
• 6307-83-1 3-bromo-5-nitro-benzoic acid 
• 17601-94-4 2-amino-3-bromo-5-nitrobenzonitrile 

Downstream Products

• 49674-16-0 3-amino-5-bromo-benzonitrile 
• 1312923-96-8 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-nitrobenzonitrile 
• 1031370-96-3 3-(2-(pyridin-2-yl)ethynyl)-5-nitrobenzonitrile 
• 1312923-86-6 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrobenzonitrile 
• 1312923-92-4 3-(2-(6-methylpyridin-2-yl)ethynyl)-5-nitrobenzonitrile 
• 1445880-69-2 5-(3-(cyclopent-1-en-1-yl)-5-nitrophenyl)-2H-tetrazole 
• 1445879-44-6 N-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-((4-fluorophenyl)amino)-5-(2H-tetrazol-5-yl)phenyl)amino)quinoline-3-sulfonamide 
• 1445880-68-1 3-(cyclopent-1-en-1-yl)-5-nitrobenzonitrile 
• 1445791-88-7 N-hydroxy-3-nitro-5-((3-(trifluoromethyl)phenyl)amino)benzimidamide 
• 1445788-40-8 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-((4-fluorophenyl)amino)-5-(2H-tetrazol-5-yl)phenyl)amino)quinoline-3-sulfonamide 
• 1445791-78-5 N-(4-fluorophenyl)-3-nitro-5-(2H-tetrazol-5-yl)aniline 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Compound of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y and G are as defined in the description, and their use in the manufacture of medicaments.

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)