496771-87-0

Upstream product

• 141436-58-0 (-)-(1R)-1-[(4R,5S)-5-((1S)-1-hydroxyallyl)-2,2-dimethyl[1,3]dioxolan-4-yl]ethane-1,2-diol 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 103-49-1 dibenzylamine 

Downstream Products

• 496771-93-8 (5S)-5-[(1R,2R,3R)-4-(N,N-dibenzylamino)-2,3-isopropylidenedioxy-1-methanesulfonyloxybutyl]tetrahydrofuran-2-one 
• 496771-91-6 (5R)-5-[(1S,2R,3R)-4-(N,N-dibenzylamino)-1-hydroxy-2,3-isopropylidenedioxybutyl]tetrahydrofuran-2-one 
• 496771-89-2 methyl (E)-(6S,7R)-8-(N,N-dibenzylamino)-6,7-isopropylidenedioxy-4-octenoate 

Relevant academic research and scientific papers

A synthesis of (1S,2R,8R,8aR)-8-hydroxy-1,2-(isopropylidinedioxy)indolizidin-5-one from D-ribose: Improved access to (-)-swainsonine and its analogs

A short synthesis of the lactam (4), (1S,2R,8R,8aR)-8-hydroxy-1,2-(isopropylidenedioxy)indolizidin-5-one, from D-ribose is reported. This compound is a useful intermediate for the synthesis of analogs of the anticancer agent swainsonine (1) as well for sw