496771-89-2

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 496771-87-0 (2R,3S,4S)-1-(N,N-dibenzylamino)-2,3-isopropylidenedioxyhex-5-ene-4-ol 
• 141436-58-0 (-)-(1R)-1-[(4R,5S)-5-((1S)-1-hydroxyallyl)-2,2-dimethyl[1,3]dioxolan-4-yl]ethane-1,2-diol 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 

Downstream Products

• 496771-91-6 (5R)-5-[(1S,2R,3R)-4-(N,N-dibenzylamino)-1-hydroxy-2,3-isopropylidenedioxybutyl]tetrahydrofuran-2-one 
• 496771-93-8 (5S)-5-[(1R,2R,3R)-4-(N,N-dibenzylamino)-2,3-isopropylidenedioxy-1-methanesulfonyloxybutyl]tetrahydrofuran-2-one 

Relevant academic research and scientific papers

A synthesis of (1S,2R,8R,8aR)-8-hydroxy-1,2-(isopropylidinedioxy)indolizidin-5-one from D-ribose: Improved access to (-)-swainsonine and its analogs

A short synthesis of the lactam (4), (1S,2R,8R,8aR)-8-hydroxy-1,2-(isopropylidenedioxy)indolizidin-5-one, from D-ribose is reported. This compound is a useful intermediate for the synthesis of analogs of the anticancer agent swainsonine (1) as well for sw