49678-03-7

Usage

Uses

Used in Pharmaceutical Industry:
(2E,4E)-5-(4-chlorophenyl)penta-2,4-dienal is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex organic molecules.
Used in Agrochemical Industry:
(2E,4E)-5-(4-chlorophenyl)penta-2,4-dienal is used as an intermediate in the synthesis of agrochemicals for its potential to be part of compounds that can be used in agricultural applications.
Used in Fragrance Production:
(2E,4E)-5-(4-chlorophenyl)penta-2,4-dienal is used as a precursor in the production of fragrances for its ability to contribute to the creation of desired scents.
Used in Flavoring Industry:
(2E,4E)-5-(4-chlorophenyl)penta-2,4-dienal is used as a precursor in the production of flavorings for its potential to be part of compounds that can enhance or create flavors in food products.
Used in Organic Synthesis:
(2E,4E)-5-(4-chlorophenyl)penta-2,4-dienal is used as a precursor for the synthesis of various organic compounds due to its reactive functional groups and structural features.

Upstream product

• 36382-29-3 1-Chloro-4-((E)-3,5,5-triethoxy-pent-1-enyl)-benzene 
• 32271-56-0 (E)-4-(4-chlorophenyl)but-3-en-2-ol 
• 68-12-2 N,N-dimethyl-formamide 
• 1346459-93-5 (E)-4-(4-chlorophenyl)-1-(trimethylsilyl)but-3-en-1-yne 
• 66482-29-9 1-[(E)-2-bromoethenyl]-4-chlorobenzene 
• 66482-29-9 1-(2-bromovinyl)-4-chlorobenzene 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 
• 104-88-1 4-chlorobenzaldehyde 
• 201230-82-2 carbon monoxide 
• 53081-61-1 (E)-1-(but-1-en-3-yn-1-yl)-4-chlorobenzene 
• 39806-17-2 Ethyl 5-(4-chlorophenyl)-2,4-pentadienoate 
• 30626-03-0 (3E)-4-(4-chlorophenyl)-3-buten-2-one 
• 942491-80-7 (2E,4E)-5-(4-chlorophenyl)-2,4-pentadien-1-ol 
• 103698-50-6 triphenylarsonium salt of bromoacetaldehyde 

Downstream Products

• 15542-34-4 5-(4-chlorophenyl)penta-(2E,4E)-dienoic acid 
• 129422-77-1 9-(4'-chlorophenyl)-2,4,6,8-nonatetraenal 

Relevant academic research and scientific papers

Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π-Acceptor Biphosphoramidite Ligand

The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.

Palladium(II) and palladium(0)-cocatalyzed ring opening and oxidation reactions of 2-(arylmethylene)cyclopropylcarbinols

In the presence of Pd(II) acetate and triethylamine as well as triphenylphosphine, 2-(arylmethylene)cyclopropylcarbinols 1 underwent ring opening and oxidation reactions smoothly to deliver (2E,4E)-5-arylpenta-2,4-dienals 2 in toluene at 60 °C in moderate

Formation of acetaldehyde enolate from vinyl acetate and its reaction with aromatic and heterocyclic aldehydes: An efficient synthesis of enals and polyenals

Two carbon homologation of aromatic and heterocyclic aldehydes is achieved by reacting them with acetaldehyde enolate anion generated in situ by cleaving vinyl acetate in the presence of barium hydroxide.

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.

A stereoselective synthesis of unsaturated phosphonates by Wittig-Horner reactions of bisphosphonylmethane with 5-aryl-(3-methyl)-2E,4E-pentadienals

A new type of unsaturaled phosphonates 5 were synthesized by the Wittig-Horner reactions of bisphosphonylmethane 4 with 5-aryl-2(E),4(E)-pentadienal and 5-aryl-3-methyl-2(E), 4(E)-pentadienal. The structures of all new compounds prepared were characterize

Synthesis of (2E,4E)-dienals by double formyl-olefination with an arsonium salt and its application in the syntheses of lipoxygenase metabolites of arachidonic acid

A new facile route to (2E,4E)-dienals by a double formyl-olefination with arsonium salts has been developed. By this method and with other arsonium reagents in the key step some lipoxygenase metabolites of arachidonic acid, lipoxin A4 and B4 and leukotriene B4, have been synthesized.