39806-17-2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 97856-61-6 3-Ethoxycarbonylallylidenetriphenylarsorane 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1075-77-0 (E)-4-chlorocinnamic aldehyde 
• 97856-60-5 3-Ethoxycarbonylallylidenetriphenylarsonium bromide 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 10236-14-3 4-(diethoxyphosphoryl)-but-2-enoic acid ethyl ester 

Downstream Products

• 49678-03-7 (2E,4E)-5-(4'-chlorophenyl)-2,4-pentadienol 
• 371111-51-2 5-(4-chloro-phenyl)-pentanoic acid ethyl ester 
• 942491-80-7 (2E,4E)-5-(4-chlorophenyl)-2,4-pentadien-1-ol 

Relevant academic research and scientific papers

Cobalt-Catalyzed Diastereo- And Enantioselective Reductive Allyl Additions to Aldehydes with Allylic Alcohol Derivatives via Allyl Radical Intermediates

Catalytic generation of ambiphilic π-allyl-metal complexes and their utility in enantioselective transformations constitutes a powerful approach for introduction of allyl groups to a molecule. Herein an unprecedented cobalt-catalyzed highly site-, diastereo-, and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes is presented. The reaction features diastereo- and enantioconvergent conversion of easily accessible allylic alcohol derivatives to diversified enantioenriched homoallylic alcohols with a remarkably broad scope of allyl groups that can be introduced. Mechanistic studies indicated that allyl radical intermediates were involved in this process. These new discoveries establish a new strategy for development of enantioselective transformations through capture of radicals by chiral Co complexes, pushing forward the frontier of Co complexes for enantioselective catalysis.

Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides

Syntheses of (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides are described, some of which are potent inhibitors of histone deacetylase, a double bond conferring more than a 10-fold increase in potency compared with the triple bond analogue oxamflatin.

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.