496789-48-1

Upstream product

• 1227186-34-6 C₃₃H₃₀BrN₅O₇ 
• 496789-54-9 2-benzyloxycarbonylamino-3-(3-{3-[4-benzyloxymethyl-2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-oxazol-5-yl]-7-bromo-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl}-4-methoxymethoxy-phenyl)-propionic acid 
• 496789-45-8 2-benzyloxycarbonylamino-3-(3-{3-[4-benzyloxymethyl-2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-oxazol-5-yl]-7-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl}-4-hydroxy-phenyl)-propionic acid methyl ester 
• 496789-44-7 (S)-3-(3-{3-[2-((S)-1-Amino-2-methyl-propyl)-4-benzyloxymethyl-oxazol-5-yl]-7-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 793727-79-4 {1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester 
• 496789-39-0 (S)-2-(1-tert-butoxycarbonylamino-2-methyl)propyloxazole-4-methanol benzyl ether 
• 158068-94-1 (S)-2-((S)-1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-4,5-dihydrooxazole-4-carboxylic acid methyl ester 
• 71017-98-6 methyl (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoate 
• 13734-41-3 t-Boc-L-valine 
• 158068-97-4 2-<(S)-1--2-methylpropyl>-4-carbomethoxyoxazole 
• 496789-53-8 (S)-2-(1-tert-butoxycarbonylamino-2-methyl)propyloxazole-4-methanol 

Downstream Products

• 496789-56-1 C₃₈H₃₉BrN₄O₉ 
• 793728-21-9 C₃₈H₃₇BrN₄O₉ 
• 496789-57-2 C₃₈H₃₇BrN₄O₁₀ 
• 496789-58-3 C₄₈H₄₃BrN₆O₉ 
• 496789-50-5 C₄₈H₄₂N₆O₉ 
• 496789-49-2 C₄₈H₄₅BrN₆O₁₀ 

Relevant academic research and scientific papers

A concise formal synthesis of diazonamide a by the stereoselective construction of the C10 quaternary center

(Figure Presented) Protecting groups are overrated! A formal total synthesis of diazonamide A is described. The key step in this synthesis is an intramolecular SNAr reaction between an oxindole and a bromooxazole. Interestingly, this reaction proceeds bes

Chemistry and biology of diazonamide A: First total synthesis and confirmation of the true structure

With the addition of a tenth ring, the exchange of an oxygen atom for a nitrogen in the heart of the molecule, and a different terminal residue, the revised architecture for diazonamide A (1) provided an even more challenging molecular puzzle for chemical synthesis than its predecessor. In this article, we detail the first successful total synthesis of diazonamide A, an endeavor which not only verified its proper connectivities and established the stereochemistry of its previously unassignable C-37 chiral center, but which also was attended by the development of several new synthetic strategies and tactics.