496811-01-9Relevant articles and documents
Application of polymer-supported enzymes and reagents in the synthesis of γ-aminobutyric acid (GABA) analogues
Baxendale, Ian R.,Ernst, Martin,Krahnert, Wolf-Rüdiger,Ley, Steven V.
, p. 1641 - 1644 (2007/10/03)
Polymer-supported pig liver esterase was used for the resolution of meso-diesters. The enzyme can be recovered quantitatively from the reaction mixture by filtration and reused without significant loss of activity. Further transformation of the resulting enantiomerically enriched carboxylic acids through the application of polymer-supported reagents and scavengers provides a number of GABA-analogues.