496863-41-3

Upstream product

• 3282-30-2 pivaloyl chloride 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 101010-59-7 2,2,-bis(methylsulfanyl)acetaldehyde 
• 496863-47-9 N-acetyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2-dimethylpropanamide 

Downstream Products

• 496863-42-4 2,2-dimethylpropanoic acid 1-[bis(methylsulfanyl)methyl]-3-{(but-3-enoyl)[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-oxopropyl ester 
• 496863-44-6 1-[2-(3,4-dimethoxyphenyl)ethyl]-6-(methylsulfanyl)-2,3,3a,4,5,6-hexahydro-1H-indole-2,5-dione 
• 496863-45-7 1-[2-(3,4-dimethoxyphenyl)ethyl]-2,3,3a,4,5,6-hexahydro-1H-indole-2,5-dione 
• 496863-43-5 N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[5-(methylsulfanyl)furan-2-yl]but-3-enamide 

Relevant academic research and scientific papers

A new construct of the cis-3a-aryloctahydroindole skeleton via the [4+2] cycloaddition of furanyl carbamates

Several 2-methylthio-5-amidofurans containing tethered unsaturation were prepared via the reaction of dimethyl(methylthio)-sulfonium tetrafluoroborate (DMTSF) with β-alkoxy-γ-dithiane amides. Thermolysis of these furans resulted in an intramolecular Diels-Alder reaction (IMDAF). The resulting oxa-bridged cycloadducts underwent a subsequent rearrangement to form bicyclic lactams. Model studies were directed toward mesembrine as well as the core skeleton of the 3,4-benzoerythrinane skeleton. Using this cascade sequence, a formal synthesis of the alkaloid erysotrine was accomplished.