496864-15-4 Usage
Uses
Used in Pharmaceutical Industry:
RP106 is used as a pharmaceutical agent for its potent inhibitory effects on various cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3). Its ability to selectively target these proteins makes it a valuable compound in the development of therapies for conditions related to the dysregulation of these proteins.
Used in Cancer Research:
RP106 is used as a research tool in cancer biology for its inhibitory effects on Cdk1/cyclin B, which plays a crucial role in cell cycle regulation and has been implicated in the development and progression of various cancers. By targeting this protein complex, RP106 can provide insights into the mechanisms underlying cancer cell proliferation and contribute to the development of novel cancer treatments.
Used in Neurodegenerative Disease Research:
RP106 is used as a research compound in the study of neurodegenerative diseases due to its inhibitory effects on Cdk5/p35. Dysregulation of this protein complex has been associated with several neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. RP106 can help researchers understand the role of Cdk5/p35 in these diseases and potentially lead to the development of new therapeutic strategies.
Used in Cell Biology Research:
RP106 is used as a research tool in cell biology to investigate the role of GSK-3 in cellular processes. GSK-3 is a multifunctional kinase involved in various cellular pathways, including apoptosis, inflammation, and metabolism. By inhibiting GSK-3, RP106 can provide valuable information on the role of this kinase in cellular function and contribute to the development of targeted therapies for conditions involving GSK-3 dysregulation.
Check Digit Verification of cas no
The CAS Registry Mumber 496864-15-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,6,8,6 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 496864-15:
(8*4)+(7*9)+(6*6)+(5*8)+(4*6)+(3*4)+(2*1)+(1*5)=214
214 % 10 = 4
So 496864-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N3O/c1-3-4-5-14-15(12-6-8-13(21-2)9-7-12)20-17-16(14)18-10-11-19-17/h6-11H,3-5H2,1-2H3,(H,19,20)
496864-15-4Relevant academic research and scientific papers
Pyrrolopyrazines as kinase inhibitors
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Page 8, (2010/02/05)
The invention relates to pyrrolo [2,3b]-pyrazine derivatives having the general formula (I) : ???wherein :R2 and R3 are identical or different and represent H, C1-C6 alkyl, said alkyl being a straight or branched-chain alkyl, which can be substituted,R6 i
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
Mettey, Yvette,Gompel, Marie,Thomas, Virginie,Garnier, Matthieu,Leost, Maryse,Ceballos-Picot, Irène,Noble, Martin,Endicott, Jane,Vierfond, Jean-Michel,Meijer, Laurent
, p. 222 - 236 (2007/10/03)
Cyclin-dependent kinases (CDKs) regulate the cell cycle, apoptosis, neuronal functions, transcription, and exocytosis. The observation of CDK deregulations in various pathological situations suggests that CDK inhibitors may have a therapeutic value. In th
