4969-34-0Relevant academic research and scientific papers
Method for preparing 6-nitro-deoxy-triacetylmethyl glucoside
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Paragraph 0010; 0023-0024, (2017/09/12)
The invention discloses a method for preparing 6-nitro-deoxy-triacetylmethyl glucoside. The method comprises the following steps: S1, by taking methyl glucoside as the raw material, directly performing iodination on six primary hydroxyl groups of methyl glucoside by use of iodine, triphenylphosphine and imidazole to prepare 6-iodomethyl glucoside; S2, protecting a hydroxyl group of 6-iodomethyl glucoside by use of an acetyl group; and S3, enabling reaction between the product of S2 and sodium nitrite and phloroglucinol to obtain the target product. Physical parameters of the obtained product are consistent with descriptions of documents, and the structure is confirmed by nuclear magnetic resonance hydrogen spectrometry and nuclear magnetic resonance mass spectrometry. The method is simple and feasible in route, silica gel column chromatography is not needed after finish of each step of reaction, and the method is suitable for not only mini-preparation in a laboratory for scientific research but also industrial production amplification, and is high in efficiency and low in cost.
