496913-05-4

Upstream product

• 23891-08-9 5-phenyl-6-azauracil 
• 85118-00-9 2,6-Difluorobenzyl bromide 
• 611-73-4 Benzoylformic acid 
• 98-86-2 acetophenone 
• 38132-38-6 benzoylformic acid semicarbazone 

Downstream Products

• 496913-06-5 {2-[2-(2,6-difluoro-benzyl)-3,5-dioxo-6-phenyl-2,5-dihydro-3H-[1,2,4]triazin-4-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor

Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3, 5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds.

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, Rs