496946-78-2

Basic information

• Product Name: 5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID
• Synonyms: 5-(TRIFLUOROMETHYL)INDOLE-2-CARBOXYLIC ACID;5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID;5-(Trifluoromethyl)indole-2-carboxylic acid ,95%;5-TRIFLUOROMETHYL-1H-INDO...;5-trifluoroMethyl-1H-indoleI-2-carboxylic acid;1H-Indole-2-carboxylic acid, 5-(trifluoromethyl)-
• CAS NO: 496946-78-2
• Molecular Formula: C₁₀H₆F₃NO₂
• Molecular Weight: 229.16
• Mol File: 496946-78-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 402.5 °C at 760 mmHg
• Flash Point: 197.2 °C
• Appearance: /
• Density: 1.549 g/cm³
• Vapor Pressure: 3.35E-07mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• PKA: 4.23±0.30(Predicted)
• CAS DataBase Reference: 5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID(496946-78-2)
• EPA Substance Registry System: 5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID(496946-78-2)

Safety Data

• Hazardous Substances Data: 496946-78-2(Hazardous Substances Data)

Usage

General Description

5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C10H6F3NO2. It is a derivative of indole with a trifluoromethyl group attached to the carbon at position 5. 5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID is a carboxylic acid with potential applications in pharmaceutical and agrochemical products. It is used as a precursor in the synthesis of various pharmaceuticals and is also utilized in the development of new chemical entities. Its unique molecular structure makes it useful for the modification and enhancement of biological activity in potential drug candidates.

InChI:InChI=1/C10H6F3NO2/c11-10(12,13)6-1-2-7-5(3-6)4-8(14-7)9(15)16/h1-4,14H,(H,15,16)

Upstream product

• 127-17-3 2-oxo-propionic acid 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 455-14-1 4-trifluoromethylphenylamine 

Downstream Products

• 1362860-89-6 methyl-5-trifluoromethyl-1H-indole-2-carboxylate 
• 1228694-04-9 methyl (S)-5-(benzyloxy)-1-(chloromethyl)-3-(5-trifluoromethylindole-2-carbonyl)-1,2-dihydropyrrolo[3,2-e]indole-2-carboxylate 
• 1373438-75-5 5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION

Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis,

Acyl indoles, compositions containing such compounds and methods of use

The present invention relates to substituted indoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus and related conditions.