496953-84-5Relevant academic research and scientific papers
Facile three-component coupling procedure for the synthesis of substituted tetrahydroisoindole-1,3-diones from α,β-unsaturated aldehydes
Von Wangelin, Axel Jacobi,Neumann, Helfried,Goerdes, Dirk,Spannenberg, Anke,Beller, Matthias
, p. 2895 - 2898 (2001)
(equation presented) A new one-pot procedure for the efficient synthesis of a small library of amino-functionalized tetrahydroisoindole-1,3-dione derivatives was developed. This three-component coupling reaction comprises subsequent condensation and Diels-Alder reactions of ubiquitous available starting materials (α,β-unsaturated aldehydes, amide, and maleimide). The synthesized compounds share a substituted tetrahydroisoindole motif in an endo fashion.
