49698-76-2Relevant academic research and scientific papers
Direct ortho-acetoxylation of anilides via palladium-catalyzed sp 2 C-H bond oxidative activation
Wang, Guan-Wu,Yuan, Ting-Ting,Wu, Xue-Liang
, p. 4717 - 4720 (2008)
(Chemical Equation Presented) Various anilides have been directly ortho-acetoxylated through a Pd(OAc)2-catalyzed C-H bond activation process. The amide group in anilides was found to functionalize as an elegant directing group to convert aromatic sp2 C-H bonds into C-O bonds in high regioselectivity with acetic acid as the acetate source and K 2S2O8 as the oxidant.
Ruthenium-catalyzed oxidative ortho-benzoxylation of acetanilides with aromatic acids
Padala, Kishor,Jeganmohan, Masilamani
supporting information, p. 9651 - 9653 (2013/10/08)
Substituted acetanilides reacted with aromatic acids in the presence of [{RuCl2(p-cymene)}2], AgSbF6 and (NH 4)2S2O8 in ClCH2CH 2Cl at 100 °C for 24 h yielding ortho-benzoxylated acetanilides in good to excellent yields in a highly regioselective manner via C-H bond activation. The Royal Society of Chemistry 2013.
