497-87-0

Basic information

• Product Name: Diazene, bis(2-fluorophenyl)-, 1-oxide
• CAS NO: 497-87-0
• Molecular Formula: C12H8F2N2O
• Molecular Weight: 234.205
• Mol File: 497-87-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Diazene, bis(2-fluorophenyl)-, 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Diazene, bis(2-fluorophenyl)-, 1-oxide(497-87-0)
• EPA Substance Registry System: Diazene, bis(2-fluorophenyl)-, 1-oxide(497-87-0)

Safety Data

• Hazardous Substances Data: 497-87-0(Hazardous Substances Data)

Upstream product

• 401-44-5 2,2'-difluoroazobenzene 
• 348-54-9 2-Fluoroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 454-21-7 1,2-bis(2-fluorophenyl)hydrazine 
• 401-44-5 2,2'-difluoroazobenzene 
• 448-97-5 3,3'-difluorobiphenyl-4,4'-diamine 

Relevant articles and documents

Chemoselective electrochemical reduction of nitroarenes with gaseous ammonia

Valuable aromatic nitrogen compounds can be synthesized by reduction of nitroarenes. Herein, we report electrochemical reduction of nitroarenes by a protocol that uses inert graphite felt as electrodes and ammonia as a reductant. Depending on the cell voltage and the solvent, the protocol can be used to obtain aromatic azoxy, azo, and hydrazo compounds, as well as aniline derivatives with high chemoselectivities. The protocol can be readily scaled up to >10 g with no decrease in yield, demonstrating its potential synthetic utility. A stepwise cathodic reduction pathway was proposed to account for the generations of products in turn.

Selective Oxidation of Anilines to Azobenzenes and Azoxybenzenes by a Molecular Mo Oxide Catalyst

Aromatic azo compounds, which play an important role in pharmaceutical and industrial applications, still face great challenges in synthesis. Herein, we report a molybdenum oxide compound, [N(C4H9)4]2[Mo6O19] (1), catalyzed selective oxidation of anilines with hydrogen peroxide as green oxidant. The oxidation of anilines can be realized in a fully selectively fashion to afford various symmetric/asymmetric azobenzene and azoxybenzene compounds, respectively, by changing additive and solvent, avoiding the use of stoichiometric metal oxidants. Preliminary mechanistic investigations suggest the intermediacy of highly active reactive and elusive Mo imido complexes.

A Green Chemoenzymatic Process for the Synthesis of Azoxybenzenes

An efficient chemoenzymatic process for the synthesis of azoxybenzenes was developed. A peracid was generated in situ by Novozym 435, and then a range of anilines were oxidized by the produced peracid to afford azoxybenzenes in yields ranging from 63.1 to 94.1 %. This method expands the application of lipase in organic synthesis and provides an alternative method for the synthesis of azoxybenzenes.