401-44-5

Basic information

• Product Name: 2,2'-difluoroazobenzene
• Synonyms: 2,2'-difluoroazobenzene
• CAS NO: 401-44-5
• Molecular Weight: 218.206
• Mol File: 401-44-5.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 2,2'-difluoroazobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-difluoroazobenzene(401-44-5)
• EPA Substance Registry System: 2,2'-difluoroazobenzene(401-44-5)

Safety Data

• Hazardous Substances Data: 401-44-5(Hazardous Substances Data)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 62-53-3 aniline 
• 1227476-15-4 Azobenzene 
• 3296-04-6 1-azido-2-fluorobenzene 
• 108-88-3 toluene 
• 76-05-1 trifluoroacetic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 497-87-0 (Z)-1,2-bis(2-fluorophenyl)diazene 1-oxide 
• 454-21-7 1,2-bis(2-fluorophenyl)hydrazine 

Downstream Products

• 454-21-7 1,2-bis(2-fluorophenyl)hydrazine 
• 497-87-0 (Z)-1,2-bis(2-fluorophenyl)diazene 1-oxide 
• 1647097-06-0 (E)-1-(2-fluoro-6-nitrophenyl)-2-(2-fluorophenyl)diazene 
• 5509-65-9 2,6-difluoroaniline 
• 1447966-67-7 (E)-1-(2-bromo-6-fluorophenyl)-2-(2-fluorophenyl)diazene 
• 1440357-04-9 C₂₂H₂₆F₂N₂ 
• 448-97-5 3,3'-difluorobiphenyl-4,4'-diamine 

Relevant articles and documents

A laser flash photolysis and quantum chemical study of the fluorinated derivatives of singlet phenylnitrene

Laser flash photolysis (LFP, Nd:YAG laser, 35 ps, 266 nm, 10 mJ or KrF excimer laser, 10 ns, 249 nm, 50 mJ) of 2-fluoro, 4-fluoro, 3,5-difluoro, 2,6-difluoro, and 2,3,4,5,6-pentafluorophenyl azides produces the corresponding singlet nitrenes. The singlet

Selective Oxidation of Anilines to Azobenzenes and Azoxybenzenes by a Molecular Mo Oxide Catalyst

Aromatic azo compounds, which play an important role in pharmaceutical and industrial applications, still face great challenges in synthesis. Herein, we report a molybdenum oxide compound, [N(C4H9)4]2[Mo6O19] (1), catalyzed selective oxidation of anilines with hydrogen peroxide as green oxidant. The oxidation of anilines can be realized in a fully selectively fashion to afford various symmetric/asymmetric azobenzene and azoxybenzene compounds, respectively, by changing additive and solvent, avoiding the use of stoichiometric metal oxidants. Preliminary mechanistic investigations suggest the intermediacy of highly active reactive and elusive Mo imido complexes.

Visible-light-promoted oxidative dehydrogenation of hydrazobenzenes and transfer hydrogenation of azobenzenes

Azo compounds are widely used in the pharmaceutical and chemical industries. Here, we report the use of a non-metal photo-redox catalyst, Eosin Y, to synthesize azo compounds from hydrazine derivatives. The use of visible-light with air as the oxidant makes this process sustainable and practical. Moreover, the visible-light-driven, photo-redox-catalyzed transfer hydrogenation of azobenzenes is compatible with a series of hydrogen donors such as phenyl hydrazine and cyclic amines. Compared with traditional (thermal/transition-metal) methods, our process avoids the issue of over-reduction to aniline, which extends the applicability of photo-redox catalysis and confirms it as a useful tool for synthetic organic chemistry.