49703-58-4

Basic information

• Product Name: (4-fluorophenyl)(phenyl)methanamine hydrochloride
• Synonyms: (4-fluorophenyl)(phenyl)methanamine hydrochloride
• CAS NO: 49703-58-4
• Molecular Weight: 237.704
• Mol File: 49703-58-4.mol

Chemical Properties

• CAS DataBase Reference: (4-fluorophenyl)(phenyl)methanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluorophenyl)(phenyl)methanamine hydrochloride(49703-58-4)
• EPA Substance Registry System: (4-fluorophenyl)(phenyl)methanamine hydrochloride(49703-58-4)

Safety Data

• Hazardous Substances Data: 49703-58-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(4-Fluorophenyl)(phenyl)methanamine hydrochloride is used as a research chemical for studying the effects of stimulant and entactogenic drugs on the human body. Its structural similarity to MDMA makes it a valuable compound for understanding the mechanisms of action and potential therapeutic applications of such substances.
Used in Drug Development:
In the pharmaceutical industry, (4-fluorophenyl)(phenyl)methanamine hydrochloride is used as a starting material or intermediate in the synthesis of other psychoactive compounds with potential therapeutic uses. Its unique properties and effects on neurotransmitter release make it a valuable tool in the development of new medications for various conditions.
Used in Forensic Toxicology:
(4-Fluorophenyl)(phenyl)methanamine hydrochloride is utilized in forensic toxicology as a reference compound for the identification and analysis of amphetamine-related substances in biological samples. This helps in the detection and quantification of these substances in cases of drug abuse or poisoning.

Upstream product

• 91-00-9 Benzhydrylamine 
• 100-46-9 benzylamine 
• 108-86-1 bromobenzene 
• 62506-88-1 N-benzylidenediphenylmethanamine 
• 1401955-78-9 N-(diphenylmethylene)-1-(4-fluorophenyl)methanamine 
• 7699-79-8 benzhydrylidene-benzyl-amine 

Relevant articles and documents

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed. This journal is the Partner Organisations 2014.

METHODS OF PREPARING PRIMARY, SECONDARY AND TERTIARY CARBINAMINE COMPOUNDS IN THE PRESENCE OF AMMONIA

The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH4+X-, by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.