49705-99-9

Usage

Uses

Used in Animal Feed Industry:
L-threonine is used as a nutritional supplement in animal feed to ensure a balanced diet for livestock, promoting optimal growth and health. Its inclusion helps meet the essential amino acid requirements for various animal species, enhancing overall feed quality and nutritional value.
Used in Pharmaceutical Industry:
L-threonine serves as a potential therapeutic agent for the treatment of neurological disorders and liver diseases. Its role in protein synthesis and tissue repair makes it a valuable component in the development of medications targeting these health conditions, offering new avenues for treatment and recovery.
Used in Food and Beverage Industry:
In the food and beverage sector, L-threonine is utilized as a flavor enhancer and a building block for the synthesis of certain amino acids, contributing to the taste and nutritional profile of various products.
Used in Cosmetics Industry:
L-threonine is incorporated into cosmetic formulations for its moisturizing and skin-repairing properties, making it a beneficial ingredient in skincare products aimed at maintaining skin health and appearance.
Used in Research and Development:
In scientific research, L-threonine is employed as a key component in the study of protein synthesis, cell metabolism, and various biological processes, furthering our understanding of its functions and potential applications in medicine and biotechnology.

InChI:InChI=1/C4H10N2O2/c1-2(7)3(5)4(6)8/h2-3,7H,5H2,1H3,(H2,6,8)

Upstream product

• 3373-59-9 (+/-)-threonine methyl ester hydrochloride 
• 3373-59-9 allo-Thr-OMe 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 3373-59-9 L-threonine methyl ester 
• 72-19-5 L-threonine 
• 49705-98-8 benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate 

Downstream Products

• 80082-48-0 t-butyloxycarbonyl-L-threonine amide 
• 1621581-60-9 benzyl 2-(2-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 118355-39-8 N-CBZ-L-Tyr-L-Thr-NH₂ 
• 1549792-00-8 (2S,3R)-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-hydroxybutanamide 
• 1549792-04-2 (2S,3R)-2-((R)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-hydroxybutanamide 
• 33209-01-7 L-threonine amide hydrochloride 
• 80082-49-1 (2S,3R)-3-Hydroxy-2-phenylacetylamino-butyramide 
• 49705-98-8 benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate 
• 129678-28-0 Bz-Tyr-Thr-NH₂ 
• 126530-15-2 acetyltyrosyl-threonine amide 
• 126530-19-6 acetyltyrozine-glycyl-leucine 

Relevant academic research and scientific papers

Synthesis method of aztreonam main ring synthesis intermediate N-carbobenzoxy-L-threonine amide

The invention provides a synthesis method of aztreonam main ring synthesis intermediate N-carbobenzoxy-L-threonine amide, which comprises the following steps: 1) adding an L-threonine solid and methanol into a reaction kettle, stirring, cooling, dropwisely adding thionyl chloride, carrying out heating reflux reaction, and drying a solvent by distillation; (2) adding methanol into a reactant obtained in the step (1) for dissolving, heating and pressurizing, introducing liquid ammonia, keeping the temperature and the pressure, evaporating the liquid ammonia after the reaction is finished, and evaporating the solvent to dryness; and 3) adding water into a reaction product obtained in the step 2) for dissolving, dropwise adding benzyl chloroformate, dropwise adding an acid-binding agent solution to control the pH value of the reaction system to obtain intermediate N-carbobenzoxy-L-threonine amide, and carrying out filter pressing and drying to obtain a solid.

PROCESS AND INTERMEDIATES FOR SYNTHESIS OF PEPTIDE COMPOUNDS

Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.

HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION

The invention pertains to the synthesis, isolation, and characterization of hemiaminal for selective labeling of peptides, proteins, antibodies, and organic fragments with -C(=0) CH2NH2 and derivatives with -CH2NH2 group over -C(=0) CHRNH2 group (where R≠H). The invention also pertains to the method of single-site immobilization of proteins through N-terminus Gly on solid phase. The invention includes late-stage tagging of N-terminus Gly with an affinity tag, 19F NMR probe, and a fluorophore and a method for metal-free protein purification and isolation of analytically pure proteins.

Synthetic method for chiral alpha-aminoamide compounds

The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.

PROCESSES FOR SYNTHESIS OF DIPYRROLIDINE PEPTIDE COMPOUNDS

Disclosed is a new process for preparing dipyrrolidine peptide compounds such as, for example, GLYX-13. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.

Novel method for preparing levetiracetam

The invention discloses a novel method for preparing levetiracetam. The method employs L-threonine as a raw material and is used to prepare levetiracetam through steps of amidation of carboxyl, acylation of amino, cyclization, sulfonylation, reduction and the like. The provided method for preparing levetiracetam employs the raw material natural amino acid L-threonine, the raw material source is wide and low in price, the reaction demanded conditions and the reaction process are simple, the total yield is relatively high, and the method is suitable for industrialized production.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Preparation of amino acid amides

A process for making amino acid amides, comprising reacting an amino acid, or acid salt of an amino acid, with a halogenating agent, or with a substance that reacts with carboxylic acids to form a leaving group, to form an intermediate, then reacting the intermediate with ammonia. When the amino acid or acid salt is enantiomerically pure, the amide will be a stereoisomer. An amide made by the process can be used to form levetiracetam.

Monobactams. Stereospecific Synthesis of (S)-3-Amino-2-oxoazetidine-1-sulfonic Acids

A facile, stereospecific synthesis of 3-amino-2-oxoazetidine-1-sulfonic acids (monobactams) by the cyclization of acyl sulfamates derived from β-hydroxy amino acids is described.