497067-40-0Relevant academic research and scientific papers
Efficient synthesis of novel 1α-amino and 3β-amino analogues of 1α,25-dihydroxyvitamin D3
Oves, Daniel,Ferrero, Miguel,Fernandez, Susana,Gotor, Vicente
, p. 1154 - 1157 (2007/10/03)
Convenient synthetic routes to 1α-amino-25-hydroxyvitamin D3 (3) and 3β-amino-3-deoxy-1α,25-dihydroxyvitamin D3 (4), novel analogues of vitamin D3 bearing an amino group at the C-1 or C-3 position, have been developed starting from (S)-(+)-carvone. Construction of the A-ring fragments was accomplished by selective enzymatic hydrolysis of a diester intermediate and introduction of the amino group under Mitsunobu conditions.
