49713-50-0Relevant academic research and scientific papers
8,8′-(Benzo[c][1,2,5]thiadiazole-4,7-diyl)bis(quinolin-4(1H)-one): a twisted photosensitizer with AIE properties
Broumidis, Emmanouil,Jones, Callum M. S.,Koyioni, Maria,Kourtellaris, Andreas,Lloyd, Gareth O.,Marques-Hueso, Jose,Koutentis, Panayiotis A.,Vilela, Filipe
, p. 29102 - 29107 (2021/10/08)
A new benzothiadiazole (BTZ) luminogen is preparedviathe Suzuki-Miyaura Pd-catalysed C-C cross-coupling of 8-iodoquinolin-4(1H)-one and a BTZ bispinacol boronic ester. The rapid reaction (5 min) affords the air-, thermo-, and photostable product in 97% yield as a yellow precipitate that can be isolated by filtration. The luminogen exhibits aggregated-induced emission (AIE) properties, which are attributed to its photoactive BTZ core and nonplanar geometry. It also behaves as a molecular heterogeneous photosensitizer for the production of singlet oxygen under continuous flow conditions.
Mechanism-Based Design of Quinoline Potassium Acyltrifluoroborates for Rapid Amide-Forming Ligations at Physiological pH
Bode, Jeffrey W.,Da Ros, Sara,Dzeng, Yi-Chung,Lam, Erwin,Tanriver, Matthias
, p. 17557 - 17565 (2021/11/04)
Potassium acyltrifluoroborates (KATs) undergo chemoselective amide-forming ligations with hydroxylamines. Under aqueous, acidic conditions these ligations can proceed rapidly, with rate constants of ～20 M-1 s-1. The requirement for lower pH to obtain the
A one-pot, two-step synthesis of 3-deazacanthin-4-ones via sequential Pd-catalyzed Suzuki-Miyaura and Cu-catalyzed Buchwald-Hartwig reactions
Broumidis, Emmanouil,Koutentis, Panayiotis A.
, p. 2661 - 2664 (2017/06/14)
3-Deazacanthin-4-one and nine analogues, including the 8-aza analogue, were prepared rapidly and in high yields from 8-iodoquinolones and 2-chloro(het)arylboronic acids. The strategy involves construction of the central B ring via concomitant Pd-catalyzed
FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
-
Page 259, (2008/06/13)
The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complica
