874831-34-2Relevant academic research and scientific papers
Mechanism-Based Design of Quinoline Potassium Acyltrifluoroborates for Rapid Amide-Forming Ligations at Physiological pH
Bode, Jeffrey W.,Da Ros, Sara,Dzeng, Yi-Chung,Lam, Erwin,Tanriver, Matthias
, p. 17557 - 17565 (2021/11/04)
Potassium acyltrifluoroborates (KATs) undergo chemoselective amide-forming ligations with hydroxylamines. Under aqueous, acidic conditions these ligations can proceed rapidly, with rate constants of ~20 M-1 s-1. The requirement for lower pH to obtain the
