49713-51-1

Basic information

• Product Name: 6-(TRIFLUOROMETHYL)QUINOLIN-4-OL
• Synonyms: BUTTPARK 10\01-36;6-(TRIFLUOROMETHYL)QUINOLIN-4-OL;6-(TRIFLUOROMETHYL)-4-QUINOLINOL;4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE;6-(Trifluoromethyl)quinolin-4-ol, 4-Hydroxy-6-(trifluoromethyl)-1-azanaphthalene
• CAS NO: 49713-51-1
• Molecular Formula: C₁₀H₆F₃NO
• Molecular Weight: 213.16
• Product Categories: Heterocycles
• Mol File: 49713-51-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 265 °C
• Boiling Point: 269.1 °C at 760 mmHg
• Flash Point: 116.6 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 0.00738mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: 6-(TRIFLUOROMETHYL)QUINOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(TRIFLUOROMETHYL)QUINOLIN-4-OL(49713-51-1)
• EPA Substance Registry System: 6-(TRIFLUOROMETHYL)QUINOLIN-4-OL(49713-51-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 49713-51-1(Hazardous Substances Data)

Usage

General Description

6-(Trifluoromethyl)quinolin-4-ol, also known as TFQ, is an organic compound with the molecular formula C10H6F3NO. It is a quinoline derivative that contains a trifluoromethyl group attached to the 6-position and a hydroxyl group at the 4-position of the quinoline ring. TFQ is used in the pharmaceutical industry as a building block for synthesizing various biologically active molecules. It also exhibits potential therapeutic properties, including anti-inflammatory and antiviral activities. Additionally, TFQ has been studied for its potential use in the development of new drugs for the treatment of infectious diseases and autoimmune disorders.

InChI:InChI=1/C10H6F3NO/c11-10(12,13)6-1-2-8-7(5-6)9(15)3-4-14-8/h1-5H,(H,14,15)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 681472-89-9 2,2-dimethyl-5-[[4-(trifluoromethyl)anilino]methylene]-1,3-dioxane-4,6-dione 
• 2033-24-1 cycl-isopropylidene malonate 
• 149-73-5 trimethyl orthoformate 
• 641993-21-7 4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 71083-01-7 ethyl 4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate 
• 1228600-39-2 6-(trifluoromethyl)-2,3-dihydroquinolin-4(1H)-on 

Downstream Products

• 49713-56-6 4-chloro-6-(trifluoromethyl)quinoline 
• 1073968-95-2 1-benzyl-6-(trifluoromethyl)quinolin-4(1H)-one 
• 544716-08-7 6-(trifluoromethyl)quinoline-4-thiol 

Relevant articles and documents

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

Senexins are potent and selective quinazoline inhibitors of CDK8/19 Mediator kinases. To improve their potency and metabolic stability, quinoline-based derivatives were designed through a structure-guided strategy based on the simulated drug–target dockin

QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19

Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted qunioline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.

Oxidation method of 4-oxo-2,3-dihydroquinoline compound

The invention discloses an oxidation method of a 4-oxo-2,3-dihydroquinoline compound. The method comprises the following steps: taking the 4-oxo-2,3-dihydroquinoline compound as a raw material; addingan organic solvent, an acidifying agent and an oxidizing agent; performing oxidation reaction at 50-85 DEG C; and after the reaction is finished, performing post-treatment on the reaction liquid to obtain a 4-hydroxyquinoline compound. Various raw materials used by the preparation method disclosed by the invention are simple and easy to obtain, are industrial products and have wide sources and low price; the preparation method is simple, easy to operate and high in product yield; compared with the traditional oxidation method of the 4-oxo-2,3-dihydroquinoline compound, the method disclosed bythe invention has the advantages of being more efficient and simpler in post-treatment; and the method is especially important for the industrialization of the product.