497147-90-7

Usage

Uses

4,5-Diamino-2-chlorobenzonitrile Dihydrochloride, can be used in the development of 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine, as potent and selective urokinase-type plasminogen activator inhibitors.

Upstream product

• 172455-36-6 2-chloro-4-amino-5-nitrobenzonitrile 
• 60702-69-4 2-chloro-4-fluorobenzonitrile 
• 183325-39-5 2-chloro-4-fluoro-5-nitrobenzonitrile 

Relevant academic research and scientific papers

PHOSPHOGLYCERATE KINASE INHIBITORS

Disclosed are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined in the description. Disclosed are also the methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as phosphoglycerate kinase.

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.