49716-04-3

Upstream product

• 1745-81-9 o-Allylphenol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 77216-31-0 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-[2-(2-propenyl)phenoxy]-2-propanol 
• 23846-71-1 (S)-alprenolol 
• 81840-59-7 (S)1-(2’-allylphenoxy)-2,3-epoxypropane 
• 141987-40-8 (S)-1-(2-Allyl-phenoxy)-3-chloro-propan-2-ol 
• 141987-49-7 (R)-1-(2-Allyl-phenoxy)-3-chloro-propan-2-ol 
• 4638-04-4 1-(2-allylphenoxy)-2,3-epoxypropane 
• 142036-93-9 Acetic acid (R)-2-(2-allyl-phenoxy)-1-chloromethyl-ethyl ester 
• 142037-14-7 Acetic acid (S)-2-(2-allyl-phenoxy)-1-chloromethyl-ethyl ester 

Relevant academic research and scientific papers

4-Phenoxy-3-hydroxy-butyramidoxime derivatives

The present invention relates as new industrial products to 4-phenoxy-3-butyramidoxime derivatives, characterized in that they are selected from the group consisting of 4-(allylphenoxy)-3-hydroxy-butyramidoximes of formula: STR1 and addition salts thereof

Antihypertensive indole derivatives of phenoxypropanolamines with β-adrenergic receptor antagonist and vasodilating activity

A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl[i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), β-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with β-adrenergic receptor antagonist and vasodilating action. The structure-activity relationships in these tests are discussed.