497225-62-4

Upstream product

• 615-96-3 Ethyl 2-bromohexanoate 
• 1338547-28-6 ethyl 2-(4-bromo-2-formylphenoxy)-hexanoate 
• 1761-61-1 5-bromosalicyclaldehyde 

Downstream Products

• 437652-07-8 N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide 
• 141626-36-0 dronedarone 
• 1338547-30-0 2-n-butyl-3-{4-[3-(di-n-butylamino)-propoxyl]-benzoyl}-5-bromo-benzofuran 
• 497225-66-8 2-n-butyl-5-bromo-benzofuran 

Relevant academic research and scientific papers

METHOD FOR PREPARING 3-KETO-BENZOFURANE DERIVATIVES

The invention relates to a method for preparing 3-keto-benzofurane derivatives of the general formula: Formula (I), where R is an alkyl or aryl group, R1 is hydrogen or an alkyl or aryl group, and R2 is a substituted alkyl or phenyl group. Said preparation method involves coupling a derivative of Formula III, where X is chlorine, bromine, or iodine or a sulfonate grouping: Formula (III) with a sulfonamide derivative of the formula R—SO2—NH2 in the presence of a basic agent and a catalytic system formed of a complex between a palladium compound and a ligand.

PROCESS FOR PREPARING SULFONAMIDOBENZOFURAN DERIVATIVES

The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl group and R1 and R2 represent hydrogen or an alkyl or aryl group. According to the invention, the compounds of formula I are prepared by coupling a benzofuran derivative of general formula II, where X represents chlorine, bromine or iodine or a sulfonate group: formula (II) with a sulfonamide derivative of formula R—SO2—NH2, in the presence of a basic agent and of a catalyst system formed from a complex between a palladium compound and a ligand.