4974-05-4

Basic information

• Product Name: (R)-(-)-4'-methoxy-3-phenylbutyric acid
• Synonyms: (R)-(-)-4'-methoxy-3-phenylbutyric acid
• CAS NO: 4974-05-4
• Molecular Weight: 194.23
• Mol File: 4974-05-4.mol

Chemical Properties

• CAS DataBase Reference: (R)-(-)-4'-methoxy-3-phenylbutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-4'-methoxy-3-phenylbutyric acid(4974-05-4)
• EPA Substance Registry System: (R)-(-)-4'-methoxy-3-phenylbutyric acid(4974-05-4)

Safety Data

• Hazardous Substances Data: 4974-05-4(Hazardous Substances Data)

Upstream product

• 61292-83-9 (+/-)-ethyl 3-(4-methoxyphenyl)butanoate 
• 18310-76-4 3-(4'-methoxyphenyl)butanoyl chloride 
• 6555-30-2 3-(4-methoxyphenyl)butyric acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 19169-94-9 (Z)-3-methyl-p-methoxycinnamic acid 
• 199006-83-2 (S,R)-(+)-N-(1-ethyl-2-hydroxy)ethyl-N-(2-fluorobenzyl)-3-(p-methoxyphenyl)butanamide 
• 146137-35-1 (3(3R),4S)-4-phenyl-3-<3-(4'-methoxyphenyl)butanoyl>-2-oxazolidinone 

Downstream Products

• 128707-85-7 (S)-3-[(2R,3S)-2-Azido-3-(4-methoxy-phenyl)-butyryl]-4-benzyl-oxazolidin-2-one 
• 128693-82-3 (3(3R),4S)-4-benzyl-3-<3-(4'-methoxyphenyl)butanoyl>-2-oxazolidinone 
• 128677-84-9 (2R,3S)-2-Azido-3-(4-methoxyphenyl)butyric acid 
• 754977-47-4 (2R,3S)-2-Amino-3-(4-methoxy-phenyl)-butyric acid 
• 128573-11-5 threo-D-(2R,3S)-β-Methyltyrosine 
• 151800-32-7 (3(3R),4R)-3-<3-(4'-Methoxyphenyl)butanoyl>-4-phenyl-2-oxazolidinone 
• 154006-51-6 (R)-3-((2R,3S)-2-bromo-3-(4-methoxyphenyl)butanoyl)-4-phenyloxazolidin-2-one 
• 128677-81-6 C₁₆H₂₂O₄ 

Relevant articles and documents

Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.

Rh-catalyzed highly enantioselective synthesis of 3-arylbutanoic acids

(Chemical Equation Presented) It's in the mix: The reaction conditions - catalyst, additive, and solvent - have been optimized for the asymmetric hydrogenation of 3-aryl-3-butenoic acids. The rigid, chiral bisphospholane ligand (SP,RC)-DuanPhos is crucial to achieving high enantioselectivity.

Determination of the Enantiomeric Excesses of Chiral Acids by 19F NMR Studies of their Esters deriving from (R)-(+)-2-(Trifluoromethyl)benzhydrol

15-Chiral acids were esterified with optically pure (R)-(+)-2-(trifluoromethyl)benzhydrol (R)-(+)-1, a readily available reagent.With respect to the carboxy group, the stereogenic centre is in the β-position in the case of the acids 5a-10a and 12a-16a, and in the α position in the case of the acids 17a-20a.The diastereomeric excesses of the corresponding esters 5b-10b and 12b-20b, respectively, were easily determined by means of 19F NMR.These d.e. values were in very good agreement with the e.e. values of the corresponding acids when the latter were known compounds.

Efficient Method for the Total Asymmetric Synthesis of the Isomers of β-Methyltyrosine

α-Amino acids modified at the β-carbon atom can provide topographical constraints when incorporated into a peptide.Such modifications can modulate the physical, chemical, and biological properties of the compound.In order to properly evaluate the effect o