19169-94-9

Basic information

• Product Name: (2E)-3-(4-methoxyphenyl)but-2-enoic acid
• CAS NO: 19169-94-9
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.2112
• Mol File: 19169-94-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 339.4°C at 760 mmHg
• Flash Point: 132.7°C
• Density: 1.138g/cm³
• Vapor Pressure: 3.58E-05mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: (2E)-3-(4-methoxyphenyl)but-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-methoxyphenyl)but-2-enoic acid(19169-94-9)
• EPA Substance Registry System: (2E)-3-(4-methoxyphenyl)but-2-enoic acid(19169-94-9)

Safety Data

• Hazardous Substances Data: 19169-94-9(Hazardous Substances Data)

Usage

Description

(2E)-3-(4-methoxyphenyl)but-2-enoic acid is a carboxylic acid with a molecular formula of C11H12O3. It features a but-2-enoic acid functional group and a 4-methoxyphenyl substituent. (2E)-3-(4-methoxyphenyl)but-2-enoic acid is commonly used in organic synthesis and pharmaceutical research due to its potential therapeutic properties and is a valuable building block for the production of various drugs and biologically active molecules. The presence of the methoxy group on the phenyl ring influences the compound's reactivity and biological activity, making it an important target for further study and development in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Research:
(2E)-3-(4-methoxyphenyl)but-2-enoic acid is used as a building block for the production of various drugs and biologically active molecules. Its potential therapeutic properties make it a valuable compound for further study and development in the field of medicinal chemistry.
Used in Organic Synthesis:
(2E)-3-(4-methoxyphenyl)but-2-enoic acid is used as a key intermediate in the synthesis of complex organic molecules. Its unique structure and functional groups make it a versatile compound for use in various chemical reactions and the formation of new compounds.

Upstream product

• 3095-95-2 diethylphosphonoacetic acid 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 108454-55-3 3-(4-methoxyphenyl)-2-butenoic acid ethyl ester 
• 99142-77-5 methyl (E)-3-(3-methoxyphenyl)-3-methylacrylate 
• 7706-82-3 (E)-ethyl 3-(4-methoxyphenyl)but-2-enoate 
• 107-93-7 (E)-but-2-enoic acid 
• 696-62-8 para-iodoanisole 
• 623-48-3 ethyl iodoacetae 
• 71-43-2 benzene 
• 105-36-2 ethyl bromoacetate 
• 79672-56-3 ethyl 3-hydroxy-3-(4-methoxyphenyl)butanoate 
• 124-38-9 carbon dioxide 
• 544-97-8 dimethyl zinc(II) 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1332645-57-4 (R)-1-methyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2,6'(1H,3'H)-dione 
• 1332645-60-9 (R)-5-chloro-1-methyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2,6'(1H,3'H)-dion 
• 1332645-76-7 (RS)-5-chloro-1-methyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2,6'(1H,3'H)-dion 
• 1332645-62-1 (R)-5-fluoro-1-methyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2,6'(1H,3'H)-dione 
• 1332645-64-3 (R)-1,5-dimethyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2, 6'(1H,3'H)-dione 
• 1332645-67-6 (R)-1-benzyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2,6'(1H,3'H)-dione 
• 1332645-69-8 (R)-5-chloro-1-benzyl-4'-(4-methoxyphenyl)spiro[indoline-3,2'-pyran]-2,6'(1H,3'H) 
• 1332645-32-5 (R)-4-(4-methoxylphenyl)-6-(trifluoromethyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one 
• 1377848-19-5 (RS)-4-(4-methoxylphenyl)-6-(trifluoromethyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one 
• 6555-30-2 3-(4-methoxyphenyl)butyric acid 

Relevant articles and documents

Copper-Photocatalyzed Contra-Thermodynamic Isomerization of Polarized Alkenes

The contra-thermodynamic isomerization of α- and β-substituted cinnamate derivatives catalyzed by the Cu(OAc)2/rac-BINAP complex under blue light irradiation is reported. The use of an oxazolidinone template, which favored the complexation of the copper catalyst to the substrate, allowed the E → Z isomerization of the catalytically formed chromophore under simple and robust reaction conditions in good to excellent ratios. The mechanism of this process based on the transient formation of a chromophore was also studied.

Enantioselective epoxidation of β,β-disubstituted enamides with a manganese catalyst and aqueous hydrogen peroxide

Enantioselective epoxidation of β,β-disubstituted enamides with aqueous hydrogen peroxide and a novel manganese catalyst is described. Epoxidation is stereospecific and proceeds fast under mild conditions. Amides are disclosed as key functional groups to enable high enantioselectivity.

Construction of Multi-Substituted Benzenes via NHC-Catalyzed Reactions of Carboxylic Esters

A carbene-catalyzed ester activation reaction for the synthesis of multi-substituted benzenes is developed. Tetra-substituted benzene compounds are efficiently synthesized through this methodology. Compared with aldehyde substrates used in previous reports, the ester substrates used here are much more readily available and inexpensive. In addition, the TEMPO oxidant used here is more inexpensive than the quinones commonly used in related carbene-catalyzed reactions.