4974-45-2Relevant articles and documents
1H, 13C and 15N NMR of spiro acridines integrated with pyrrole scaffolds
Vilková, Mária,?oral, Michal,Be?ka, Michal,Poto?ňák, Ivan,Sabolová, Danica,Béres, Tibor,Du?ek, Michal,Imrich, Ján
, p. 204 - 214 (2019/12/24)
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Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives
Gouveia, Rawny Galdino,Ribeiro, Amélia Galdino,Segundo, Miguel ?ngelo Santos Pinheiro,de Oliveira, Jamerson Ferreira,de Lima, Maria do Carmo Alves,de Lima Souza, Túlio Ricardo Couto,de Almeida, Sinara M?nica Vitalino,de Moura, Ricardo Olímpio
, p. 5911 - 5921 (2018/11/23)
Nine new spiroacridine derivatives were synthetized by introducing cyano-N-acylhydrazone group between the acridine and phenyl-substituted rings followed by spontaneous cyclization. The new compounds were assayed for their DNA binding properties, human to
The Complex Reaction of Acetohydrazides with Unsaturated Diketones: Alternative Cyclizations to 1,2-Diazepin-3-ones and Pyrazolopyridines
Alonso, Paloma,Martin-Leon, Nazario,Quinteiro, Margarita,Seoane, Carlos,Soto, Jose L.
, p. 841 - 846 (2007/10/02)
The reaction of 2-cyanoacetohydrazide (1) and 2-(ethoxycarbonyl)acetohydrazide (26) with unsaturated 1,3-diketones leading with moderate yields to 1,2-diazepinones (3, 23, 24) and pyrazolopyridines (5, 15, 20, 25) together with the corresponding acetohydrazones have been studied.The reaction course depends on the temperature and the relative reactivity of the carbonyl groups of the starting materials.When one of these carbonyl groups is less reactive (benzoyl or ethoxycarbonyl groups), the reaction does not yield diazepinones but only pyrazolopyridines and/or acetohydrazones.
