4974-45-2Relevant academic research and scientific papers
7-Amino-2-aryl/hetero-aryl-5-oxo-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles: Synthesis and adenosine receptor binding studies
Shaik, Khasim,Deb, Pran Kishore,Mailavaram, Raghu Prasad,Chandrasekaran, Balakumar,Kachler, Sonja,Klotz, Karl-Norbert,Jaber, Abdul Muttaleb Yousef
, p. 1568 - 1573 (2019/05/27)
A series of novel 7-amino-5-oxo-2-substituted-aryl/hetero-aryl-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles (4a–4t) was synthesized, characterized and evaluated for their binding affinity and selectivity towards hA1, hA2A/sub
Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives
Gouveia, Rawny Galdino,Ribeiro, Amélia Galdino,Segundo, Miguel ?ngelo Santos Pinheiro,de Oliveira, Jamerson Ferreira,de Lima, Maria do Carmo Alves,de Lima Souza, Túlio Ricardo Couto,de Almeida, Sinara M?nica Vitalino,de Moura, Ricardo Olímpio
, p. 5911 - 5921 (2018/11/23)
Nine new spiroacridine derivatives were synthetized by introducing cyano-N-acylhydrazone group between the acridine and phenyl-substituted rings followed by spontaneous cyclization. The new compounds were assayed for their DNA binding properties, human to
Pyrolysis of amino nitriles, cyanohydrazones, and cyanoacetamides. Part I. Elimination reaction of 1-arylmethyleneamino-1,2-dihydro-4, 6-dimethyl-2-oxopyridine-3-carbonitriles and substituted benzaldehyde cyanoacetylhydrazones
Al-Awadi,Elnagdi,Mathew,El-Gamry,Abdel Khalik
, p. 741 - 748 (2007/10/03)
Pyrolysis of the Schiff bases of 1-arylmethyleneamino-1,2-dihydro-4, 6-dimethyl-2-oxopyridine-3-carbonitriles (1-5) has been studied. These compounds eliminate via a six-membered transition state to produce substituted benzonitriles and 2-hydroxy-4,6-dimethylpyridine-3-carbonitrile. These eliminations are unimolecular first-order reactions. The kinetic data gave a good correlation with σ0 values of the substituents on the aryl group with ρ = 0.83 at 520 K. Utilization of the pyrolytic reaction in synthesis of various benzonitriles is considered, and mechanistic information has been obtained by comparing the kinetic data and product analysis of the Schiff bases with their open-chain substituted benzaldehyde cyanoacetylhydrazones (6-9) analogues.
The Complex Reaction of Acetohydrazides with Unsaturated Diketones: Alternative Cyclizations to 1,2-Diazepin-3-ones and Pyrazolopyridines
Alonso, Paloma,Martin-Leon, Nazario,Quinteiro, Margarita,Seoane, Carlos,Soto, Jose L.
, p. 841 - 846 (2007/10/02)
The reaction of 2-cyanoacetohydrazide (1) and 2-(ethoxycarbonyl)acetohydrazide (26) with unsaturated 1,3-diketones leading with moderate yields to 1,2-diazepinones (3, 23, 24) and pyrazolopyridines (5, 15, 20, 25) together with the corresponding acetohydrazones have been studied.The reaction course depends on the temperature and the relative reactivity of the carbonyl groups of the starting materials.When one of these carbonyl groups is less reactive (benzoyl or ethoxycarbonyl groups), the reaction does not yield diazepinones but only pyrazolopyridines and/or acetohydrazones.
