4976-94-7

Basic information

• Product Name: Boc-Asp(OtBu)-Phe-OMe
• Synonyms: Boc-Asp(OtBu)-Phe-OMe
• CAS NO: 4976-94-7
• Molecular Weight: 450.532
• Mol File: 4976-94-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Asp(OtBu)-Phe-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Asp(OtBu)-Phe-OMe(4976-94-7)
• EPA Substance Registry System: Boc-Asp(OtBu)-Phe-OMe(4976-94-7)

Safety Data

• Hazardous Substances Data: 4976-94-7(Hazardous Substances Data)

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 4976-93-6 N-tert.-Butyloxycarbonyl-L-asparaginsaeure-(β-tert.-butylester)-α-(2.4.5-trichlor-phenyl-ester) 

Downstream Products

• 5910-52-1 α-L-aspartyl-L-phenylalanine methyl ester hydrochloride 
• 22839-47-0 L-Asp-L-Phe-OMe 

Relevant articles and documents

Solvent-free synthesis of peptides

Chamical Equation Presentation A crush on sweetness! The coupling of a urethane-protected N-carboxyanhydride of an amino acid with another amino acid derivative under ball-milling conditions gives a protected dipeptide in very high yield (see scheme; PG: protecting group). The reaction takes place in the solid state. The synthesis was applied to the preparation of a tri peptide and the sweetener aspartame, without any organic solvent or purification.