497830-95-2

Upstream product

• 13734-41-3 t-Boc-L-valine 
• 87694-52-8 tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate 
• 79069-51-5 (S)-N-tert-butoxycarbonylvalinal 
• 104700-38-1 (4S)-4-N-tert-butoxycarbonylamino-5-methyl-2-trans-hexenoic acid, ethyl ester 
• 100-39-0 benzyl bromide 
• 244033-79-2 (E)-(S)-4-Amino-5-methyl-hex-2-enoic acid ethyl ester 

Downstream Products

• 497830-80-5 4-[benzyl-(4-oxo-pent-2-enoyl)-amino]-5-methylhex-2-enoic acid ethyl ester 
• 497830-81-6 4-[benzyl-(4-oxo-4-phenyl-but-2-enoyl)amino]-5-methylhex-2-enoic acid ethyl ester 
• 497832-80-1 (3S,3aR,4S,7aR)-2-benzyl-3-isopropyl-1-oxo-6-phenyl-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester 
• 497830-73-6 (3S,3aR,4S,7aR)-2-benzyl-3-isopropyl-6-methyl-1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

An intramolecular oxo Diels-Alder approach to 1-oxo-1,2,3,3a,4,7a- hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters

The diastereoselective synthesis of a series of 1-oxo-1,2,3,3a,4,7a- hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters via an oxo Diels-Alder reaction is described. Ab initio calculations predicted the products of the exo cycloaddition to be the thermodynamic products while the products resulting from the endo cycloaddition were predicted to be the kinetic products. The calculations were born out by experimental data.

Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction

Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functionalized