497843-73-9Relevant academic research and scientific papers
TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS
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Page/Page column 549-550; 552-553, (2020/10/21)
Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.
IMMUNOMODULATORY COMPOUNDS
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Paragraph 0158-0160, (2020/01/24)
Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.
New catalyst systems for iron-catalyzed hydrosilane reduction of carboxamides
Tsutsumi, Hironori,Sunada, Yusuke,Nagashima, Hideo
supporting information; experimental part, p. 6581 - 6583 (2011/07/08)
A heptanuclear iron carbonyl cluster, [Fe3(CO) 11(μ-H)]2Fe(DMF)4 (4), is found to be a highly efficient catalyst for the reduction of various carboxamides by 1,2-bis(dimethylsilyl)benzene (BDSB), which makes possible reducing the amount of the catalyst, shortening the reaction time, and lowering the reaction temperatures.
Hydrosilane reduction of tertiary carboxamides by iron carbonyl catalysts
Sunada, Yusuke,Kawakami, Hiroko,Imaoka, Tsuyoshi,Motoyama, Yukihiro,Nagashima, Hideo
supporting information; experimental part, p. 9511 - 9514 (2010/03/24)
Fox in the carboxamide: Reduction of tertiary carboxamides to their corresponding amines is catalyzed by [Fe(CO)5] or [Fe 3(CO)12], using 1,1,3,3tetramethyldlsiloxane (TMDS) as the reducing agent. The reaction proceeds under either thermal or photochemical conditions. Unlike the hydrosilane reduction of amides using platinum or ruthenlum catalysts, TMDS preferentially reduces a nitro group, even in the presence of competing amides.
