497946-73-3

Upstream product

• 109364-33-2 N-(benzyloxycarbonyl)-L-norleucinal 
• 17329-20-3 (R)-(+)-α-methylbenzylisocyanide 
• 65-85-0 benzoic acid 

Downstream Products

• 568591-63-9 [1-({[2-(4-phenyl-1-piperazinyl)-4-pyrimidinyl]oxy}methyl)cyclobutyl]methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-51-5 [1-({[2-(4-methyl-1-piperazinyl)-4-pyrimidinyl]oxy}methyl)cyclobutyl]methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-77-5 [1-({[5-(4-chlorophenyl)-1-methyl-1H-imidazol-2-yl]sulfanyl}methyl)cyclobutyl]methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-53-7 [1-({[2-(4-morpholinyl)-4-pyrimidinyl]oxy}methyl)cyclobutyl]methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-75-3 [1-({[4-(4-chlorophenyl)-2-pyrimidinyl]sulfanyl}methyl)cyclobutyl]methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-71-9 [1-({[4-(4-methylphenyl)-1,3-thiazol-2-yl]oxy}methyl)cyclobutyl]methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-73-1 (1-{[(6-methyl-4-phenylpyridazin-3-yl)oxy]methyl}cyclobutyl)methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-67-3 {1-[(thieno[3,2-d]pyrimidin-4-yloxy)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 
• 568591-79-7 {1-[(4-trifluoromethyl-1,3-thiazol-2-yl)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate 

Relevant academic research and scientific papers

Design of small molecule ketoamide-based inhibitors of cathepsin K

A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P2 and P3 elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenua