497959-33-8

Basic information

• Product Name: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL
• Synonyms: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL;3-Bromo-4-(hydroxymethyl)benzotrifluoride, [2-Bromo-4-(trifluoromethyl)]methanol;Benzenemethanol, 2- bromo- 4- (trifluoromethyl) -;2-bromo-4-(trifluoromethyl)Benzenemethanol
• CAS NO: 497959-33-8
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.03
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 497959-33-8.mol

Chemical Properties

• Melting Point: 60-61
• Boiling Point: 249.1°C at 760 mmHg
• Flash Point: 104.4°C
• Appearance: /
• Density: 1.667g/cm³
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.53±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL(497959-33-8)
• EPA Substance Registry System: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL(497959-33-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 497959-33-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-(trifluoromethyl)benzyl alcohol is utilized as a key intermediate in the synthesis of various biologically active compounds. Its unique structure and properties contribute to the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4-(trifluoromethyl)benzyl alcohol is employed as a precursor in the production of pesticides. Its antimicrobial and antifungal properties are harnessed to create effective solutions for crop protection and disease management.
Used in Materials Science:
2-Bromo-4-(trifluoromethyl)benzyl alcohol is also applied in materials science for the development of novel materials with specific properties. Its chemical structure allows for the creation of materials with tailored characteristics for various applications.
Used as an Antimicrobial and Antifungal Agent:
2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL is used in the development of new pharmaceuticals and pesticides due to its inherent antimicrobial and antifungal properties, providing a foundation for creating treatments and preventive measures against microbial and fungal infections.

InChI:InChI=1/C8H6BrF3O/c9-7-3-6(8(10,11)12)2-1-5(7)4-13/h1-3,13H,4H2

Upstream product

• 328-89-2 2-bromo-4-trifluoromethyl-benzoic acid 

Downstream Products

• 657-64-7 2-bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene 
• 480438-96-8 2-bromo-1-(chloromethyl)-4-(trifluoromethyl)benzene 
• 1455358-27-6 1-(tert-butyl)-3-(2-(chloromethyl)-5-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 1455358-25-4 1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 1455358-24-3 2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-5-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.