657-64-7

Basic information

• Product Name: 2-Bromo-4-(trifluoromethyl)benzyl bromide
• Synonyms: 2-Bromo-4-(trifluoromethyl)benzyl bromide;2-bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene
• CAS NO: 657-64-7
• Molecular Formula: C₈H₅Br₂F₃
• Molecular Weight: 317.9285096
• Mol File: 657-64-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 246.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.885±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Bromo-4-(trifluoromethyl)benzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-(trifluoromethyl)benzyl bromide(657-64-7)
• EPA Substance Registry System: 2-Bromo-4-(trifluoromethyl)benzyl bromide(657-64-7)

Safety Data

• Hazardous Substances Data: 657-64-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-(trifluoromethyl)benzyl bromide is a chemical compound with the molecular formula C8H5Br2F3. It is a brominated aromatic compound that contains a trifluoromethyl group and is used as a reagent in organic synthesis. 2-Bromo-4-(trifluoromethyl)benzyl bromide is commonly employed in the pharmaceutical industry for the production of various drugs and in the synthesis of other organic compounds. It is known for its ability to react with nucleophiles and has been used in the preparation of benzyl bromides, which are versatile intermediates in organic chemistry. Additionally, it is important to handle this chemical with caution as it is a hazardous substance that can cause irritation to the skin, eyes, and respiratory system, and should be used in a well-ventilated area and with appropriate protective equipment.

Upstream product

• 328-89-2 2-bromo-4-trifluoromethyl-benzoic acid 
• 497959-33-8 (2-bromo-4-(trifluoromethyl)phenyl)methanol 
• 66417-30-9 2-bromo-1-methyl-4-(trifluoromethyl)benzene 
• 25449-96-1 3-amino-4-methylbenzotrifluoride 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 85118-24-7 2-bromo-4-(trifluoromethyl)benzaldehyde 
• 1438825-26-3 (2-butyl-5-(trifluoromethyl)phenyl)dimethylsilane 

Relevant articles and documents

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS

The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds, methods of using the compounds and methods of determining the monoacylglycerol lipase (MAGL) inhibitory activity of the compounds.

PICOLINAMIDO-PROPANOIC ACID DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.