49797-84-4

Upstream product

• 43064-09-1 [9-(benzyloxy)-3,3-dimethyl-1H,3H,5H-[1,3]dioxepino[5,6-c]-pyridin-8-yl]methanol 
• 100-39-0 benzyl bromide 
• 7442-21-9 [5-(benzyloxy)-4-(hydroxymethyl)-6-methylpyridin-3-yl]methanol 
• 49797-88-8 9-(benzyloxy)-3,3,8-trimethyl-1H,3H,5H-[1,3]dioxepino[5,6-c]-pyridin-7-ium-7-olate 
• 49797-83-3 3-benzyloxy-2,4,5-tris-hydroxymethyl-pyridine 

Downstream Products

• 62489-14-9 1-(9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carbonyl)-aziridine 
• 62489-21-8 9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester 
• 49797-89-9 9-benzyloxy-3,3-dimethyl-8-vinyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine 
• 49797-94-6 9-benzyloxy-8-(2-chloro-vinyl)-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine 
• 62489-13-8 9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid amide 
• 62489-15-0 (9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-8-yl)-carbamic acid methyl ester 

Relevant academic research and scientific papers

Origin of the Diastereoselectivity of the Heterogeneous Hydrogenation of a Substituted Indolizine

In this work, the stereoselective heterogeneous hydrogenation of a tetrasubstituted indolizine was studied. Partial hydrogenation products were obtained in three steps from a substituted pyridine-2-carboxaldehyde prepared from commercial pyridoxine hydrochloride. The hydrogenation of the indolizine ring was shown to be diastereoselective, forming trans-6b and cis-9. Theoretical calculations (ab initio and DFT) were used to rationalize the unusual trans stereoselectivity for 6b, and a keto-enol tautomerism under kinetic control has been proposed as the source of diastereoselectivity.