49798-31-4

Usage

Uses

Used in Pharmaceutical Research:
3-Phenylpyrrolidin-3-ol is used as a research chemical for studying the effects of synthetic cathinones on the central nervous system. Its psychoactive properties provide insights into the mechanisms of action and potential therapeutic applications in the treatment of various neurological disorders.
Used in Forensic Toxicology:
3-Phenylpyrrolidin-3-ol is used as a target analyte in forensic toxicology for the detection and analysis of synthetic cathinones in biological samples. Its identification in post-mortem cases or drug-impaired driving incidents helps in determining the cause of death or intoxication, respectively.
Used in Drug Regulation and Policy Development:
3-Phenylpyrrolidin-3-ol is used as a reference substance in the development of drug regulation policies and testing methods. Its inclusion in the list of controlled substances aids in monitoring and controlling the illegal distribution and consumption of synthetic cathinones, thereby reducing their potential for abuse and harm to public health.

InChI:InChI=1/C10H13NO/c12-10(6-7-11-8-10)9-4-2-1-3-5-9/h1-5,11-12H,6-8H2

Upstream product

• 92041-82-2 ethyl 3-hydroxy-3-phenyl-1-pyrrolidinecarboxylate 
• 851000-71-0 3-hydroxy-3-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 52906-59-9 3-phenyl-3-pyrroline 
• 116169-46-1 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[(3-hydroxy-3-phenyl)-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid 
• 27649-43-0 3-phenyl-1H-pyrrole 
• 97382-80-4 1-methyl-3-phenyl-3-pyrroline 
• 97382-81-5 1-methyl-3-phenyl-3-pyrroline oxalate 

Relevant academic research and scientific papers

COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present invention provides compounds of Formula (I) shown above and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.

CHIRAL AUXILIARIES

Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.

3-Pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases

We previously reported that 3-pyrroline and 3-phenyl-3-pyrroline effect a time-dependent inactivation of the copper-containing quinone-dependent amine oxidase from bovine plasma (BPAO) (Lee et al. J. Am. Chem. Soc. 1996, 118, 7241-7242). Quinone cofactor model studies suggested a mechanism involving stoichiometric turnover to a stable pyrrolylated cofactor. Full details of the model studies are now reported along with data on the inhibition of BPAO by a family of 3-aryl-3-pyrrolines (aryl = substituted phenyl, 1-naphthyl, 2-naphthyl), with the 4-methoxy-3-nitrophenyl analogue being the most potent. At the same time, the parent 3-phenyl analogue is a pure substrate for the flavin-dependent mitochondrial monoamine oxidase B from bovine liver. Spectroscopic studies (including resonance Raman) on BPAO inactivated by the 4-methoxy-3-nitrophenyl analogue are consistent with covalent derivatization of the 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor. The distinction of a class of compounds acting as an inactivator of one amine oxidase family and a pure substrate of another amine oxidase family represents a unique lead to the development of selective inhibitors of the mammalian copper-containing amine oxidases.