52906-59-9Relevant academic research and scientific papers
Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles
Scalacci, Nicoló,Black, Gary W.,Mattedi, Giulio,Brown, Nicola L.,Turner, Nicholas J.,Castagnolo, Daniele
, p. 1295 - 1300 (2017/08/09)
A chemoenzymatic cascade process for the sustainable production of pyrroles has been developed. Pyrroles were synthesized by exploiting the previously unexplored aromatizing activity of monoamine oxidase enzymes (MAO-N and 6-HDNO). MAO-N/6-HDNO whole cell biocatalysts are able to convert 3-pyrrolines into pyrroles under mild conditions and in high yields. Moreover, MAO-N can work in combination with the ruthenium Grubbs catalyst, leading to the synthesis of pyrroles from diallylamines/-anilines in a one-pot cascade metathesis-aromatization sequence.
Intramolecular redox reaction for the synthesis of N-aryl pyrroles catalyzed by Lewis acids
Du, Hong-Jin,Zhen, Le,Wen, Xiaoan,Xu, Qing-Long,Sun, Hongbin
supporting information, p. 9716 - 9719 (2015/02/19)
An efficient approach to synthesize N-aryl pyrroles via Lewis acid-mediated 1,5-hydride shift and isomerization of 2-(3-pyrroline-1-yl)arylaldehydes has been achieved in up to 89% yield. This methodology is applicable to the synthesis of fluorazene deriva
Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline
Ogunrombi, Modupe O.,Malan, Sarel F.,Terre'Blanche, Gisella,Castagnoli, Kay,Castagnoli Jr., Neal,Bergh, Jacobus J.,Petzer, Jacobus P.
, p. 458 - 467 (2008/02/05)
The neurotoxic properties of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are dependent on its metabolic activation in a reaction catalyzed by centrally located monoamine oxidase B (MAO-B). This reaction ultimately l
