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498-46-4

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498-46-4 Usage

Uses

Isoscopineis a derivative of Scopine (S199975), an intermediate in the production of Tiotropium Bromide, a long-acting bronchodilator.

Check Digit Verification of cas no

The CAS Registry Mumber 498-46-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 498-46:
(5*4)+(4*9)+(3*8)+(2*4)+(1*6)=94
94 % 10 = 4
So 498-46-4 is a valid CAS Registry Number.

498-46-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name pseudoscopine

1.2 Other means of identification

Product number -
Other names 6exo,7exo-epoxy-tropane-3exo-ol, pseudoscopine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:498-46-4 SDS

498-46-4Relevant articles and documents

Total synthesis of scopine, pseudoscopine, and nor-derivatives

Justice, David E.,Malpass, John R.

, p. 11977 - 11994 (2007/10/03)

Scopine and pseudoscopine have been synthesised from cyclohepta-3,5-dienol; the initial 1,4-functionalisation of the diene is based on a nitroso- cycloaddition. The use of the N-benzyloxycarbonyl group throughout the scheme allows ultimate reductive deprotection to yield N-methyl or novel NH (nor-) derivatives without damage to the exo-epoxide of the title compounds. Preliminary investigation of nitroso- cycloaddition to 5,6-epoxycyclohepta-1,3-diene is described.

Stereocontrolled Epoxidations of Cycloheptene Derivatives in the Palladium-Catalyzed Route to Tropane Alkaloids. Total Syntheses of Scopine and Pseudoscopine

Schink, Hans E.,Pettersson, Helena,Baeckvall, Jan-E.

, p. 2769 - 2774 (2007/10/02)

Stereoselective total syntheses of the tropane alkaloids scopine (1) and pseudoscopine (3) have been developed via the chloroacetoxylation approach.Palladium-catalyzed 1,4-chloroacetoxylation of diene 6 afforded the key intermediate 7.Subsequent substitution of the allylic chloride by TsNH- with either retention (Pd(0) catalysis) or inversion (SN2) of configuration gave 10 and 16, respectively.The epoxy oxygen was introduced syn to the nitrogen function prior to cyclization by utilizing the syn-directive effect of the allylic sulfonamido group in the epoxidation.Cyclization of the epoxides 12 and 21, followed by replacement of the tosyl group by a methyl group and subsequent debenzylation, afforded the title compounds 1 and 3, respectively.

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