4982-22-3Relevant academic research and scientific papers
Enantioselective Synthesis of cis-Decalin Derivatives by the Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones
Cai, Quan,Li, Zhan-Ting,Si, Xu-Ge,Zhang, Zhi-Mao,Zheng, Cheng-Gong
supporting information, p. 18412 - 18417 (2020/08/21)
A novel strategy for the synthesis of cis-decalins by an ytterbium-catalyzed asymmetric inverse-electron-demand Diels–Alder reaction of 2-pyrones and silyl cyclohexadienol ethers is reported here. A broad range of synthetically important cis-decalin derivatives with multiple contiguous stereogenic centers and functionalities are obtained in good yields and stereoselectivities. A full set of diastereomeric substituted cis-decalin motifs are readily accessible by tuning the absolute configurations of substituted silyl cyclohexadienol ethers (R or S) as well as the ligands (R or S). The synthetic potential is showcased by the enantioselective total synthesis of 4-amorphen-11-ol, and further demonstrated by the first total synthesis of cis-crotonin.
Palladium-Catalyzed Procedures for Annulation via Intramolecular Alkenylpalladation and Arylpalladation
Zhang, Yantao,O'Connor, Brian,Negishi, Ei-ichi
, p. 5588 - 5590 (2007/10/02)
Treatment of dienolates derived from cyclohexenes activated by carbonyl groups with γ-iodoallyl electrophiles 1 and o-iodobenzyl electrophiles 2 followed by cyclization catalyzed by Pd complexes, e.g., Pd(PPh3)4, can produce the corresponding annu
Total Synthesis of Polyether Antibiotics. Synthesis of the Enantiomer of Lasalocid A (X-537A)
Ireland, Robert E.,Courtney, Lawrence,Fitzsimmons, Brian J.
, p. 5186 - 5198 (2007/10/02)
A convergent total synthesis of the enantiomer of lasalocid A (X-537A) and the preliminary results of the biological testing of this compound are reported.
