49827-48-7Relevant academic research and scientific papers
Quantitative α-alkylation of primary nitriles
Rojas, Giovanni,Baughman, Travis W.,Wagener, Kenneth B.
, p. 3923 - 3931 (2008/03/14)
A synthetic pathway that produces alkyl α,ω-cyanodiolefins in quantitative yield is described, applying chemistry that is based on simple α-alkylation of alkyl nitriles. Three amide bases, lithium 2,2,6,6-tetramethylpiperidide, lithium diisopropylamide, and sodium amide, are used to create the α-carbanions that undergo substitution with various alkylating agents. Optimization leads to essentially quantitative conversions for every substrate/example reported herein, which will prove useful in many synthetic schemes. Copyright Taylor & Francis Group, LLC.
N,N′-disubstituted ureas: Influence of substituents on the formation of supramolecular polymers
Lortie, Frederic,Boileau, Sylvie,Bouteiller, Laurent
, p. 3008 - 3014 (2007/10/03)
Symmetrical N,N′-disubstituted ureas have been synthesized and characterized. Among them, the branched dialkylureas prepared are highly soluble in organic media. Moreover, the solutions obtained are very viscous in heptane, if the branched alkyl groups are not too bulky (i.e. a methyl group on the α carbon, or an ethyl group on the β carbon). Due to the strong, bifurcated hydrogen bonds between the urea moieties, linear supramolecular polymers are formed. The degree of association of these supramolecular polymers has been determined by FTIR spectroscopy.
