49840-80-4Relevant academic research and scientific papers
A metal-free tandem C-C/C-O bond formation approach to diversely functionalized tetrasubstituted furans
Reddy, Chada Raji,Reddy, Motatipally Damoder
, p. 106 - 116 (2014/01/17)
A novel and efficient method for the synthesis of diversely functionalized furans is developed via DBU-mediated tandem Michael addition/5-exo-dig- cycloisomerization of enynes and keto-methylenes. This [3 + 2]-annulation is operationally simple under metal-free reaction conditions with 100% atom economy and broad substrate scope.
Synthesis of substituted acetylenes, aryl-alkyl ethers, 2-alkene-4-ynoates and nitriles using heterogeneous mesoporous Pd-MCM-48 as reusable catalyst
Banerjee, Subhash,Khatri, Hari,Balasanthiran, Vagulejan,Koodali, Ranjit T.,Sereda, Grigoriy
experimental part, p. 5717 - 5724 (2011/08/21)
Pd-MCM-48 has been employed as a heterogeneous catalyst for the synthesis of substituted acetylenes via Sonogashira reactions under copper and amine-free reaction conditions. In addition, the catalyst exhibited excellent regioselectivity for primary alcohols towards C-O coupling leading to formation of alkyl-aryl ethers in high yields. A green procedure for the stereoselective synthesis of 2-alkene-4-ynoates and nitriles from the reactions of vic-(E)-diiodoalkenes with activated alkenes has also been demonstrated using Pd-MCM-48 catalyst. The catalyst was easily recovered from the reaction mixture by filtration and reused for at least six times with minimal loss of activity.
