49845-13-8

Upstream product

• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 20893-01-0 ({[(4-methylphenyl)sulfonyl]oxy}imino)malononitrile 

Downstream Products

• 130647-41-5 2-<<2-(pyrrolidin-1-yl)cyclohex-1-enyl>imino>propanedinitrile 
• 130647-45-9 1,2,5,6,7,8-hexahydro-3-oxoquinoxaline-2-carbonitrile 
• 49845-03-6 2-Amino-3-cyan-5,6-tetramethylen-pyrazin 
• 130647-44-8 5,6,7,8-tetrahydro-3-methoxyquinoxaline-2-carbonitrile 
• 107938-84-1 amino-2-methyl-1-tetrahydro-1,5,6,7-quinoxalinecarbonitrile-3 

Relevant academic research and scientific papers

2-Aza-1,3-dienes. A New Approach to Substituted 2-Aminopyrazines

Treatment of enamines by tosylated isonitrosomalono derivatives gives access to 5-dialkylamino-1,1-dicyano 2-aza-1,3-dienes (or 1-methoxycarbonyl analogous) which are precursors of various regiospecific 5,6-substituted 2-amino-3-cyano (or methoxycarbonyl) pyrazines.Some examples of utilisation of these intermediates for synthesis of lumazines, pteridines, and other bicyclic skeletons are described.