49845-25-2

Basic information

• Product Name: 1-(1-Pentenyl)piperidine
• Synonyms: 1-(1-Pentenyl)piperidine;1-(1-penten-1-yl)Piperidine
• CAS NO: 49845-25-2
• Molecular Formula: C₁₀H₁₉N
• Molecular Weight: 153.26
• Mol File: 49845-25-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(1-Pentenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Pentenyl)piperidine(49845-25-2)
• EPA Substance Registry System: 1-(1-Pentenyl)piperidine(49845-25-2)

Safety Data

• Hazardous Substances Data: 49845-25-2(Hazardous Substances Data)

Usage

General Description

1-(1-Pentenyl)piperidine is a chemical compound with the formula C12H21N. It is a piperidine derivative and is also known by the synonyms 1-pentenylpiperidine and 2-methyl-1-propyl-1-piperidine. 1-(1-Pentenyl)piperidine is an important building block in organic chemistry and is used in the synthesis of various pharmaceuticals and agrochemicals. It is a colorless to pale yellow liquid with a strong, pungent odor. 1-(1-Pentenyl)piperidine is primarily used as an intermediate in the manufacture of other chemical compounds and does not have many direct commercial applications. It should be handled with care due to its potential irritant properties.

Upstream product

• 110-89-4 piperidine 
• 110-62-3 pentanal 
• 18494-52-5 1-(piperidin-1-yl)pentan-1-one 

Downstream Products

• 99217-27-3 4-(5-propyl-2-pyridinyl)benzonitrile 
• 99217-21-7 2-(4-bromophenyl)-5-propylpyridine 
• 66661-57-2 2-(Phenylhydrazono)-pentanal 

Relevant articles and documents

An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides

A Mo(CO)6 (molybdenumhexacarbonyl) catalyzed reductive functionalization of amides to afford 5-amino substituted 4,5-dihydroisoxazoles is presented. The reduction of amides generates reactive enamines, which upon the addition of hydroximinoyl chlorides and base undergoes a 1,3-dipolar cycloaddition reaction that gives access to the desired heterocyclic compounds. The transformation of amides is highly chemoselective and tolerates functional groups such as nitro, nitriles, esters, and ketones. Furthermore, a versatile scope of 4,5-dihydroisoxazoles derived from a variety of hydroximinoyl chlorides and amides is demonstrated. (Figure presented.).

Transformation of Amides into Highly Functionalized Triazolines

Triazoles and triazolines are important classes of heterocyclic compounds known to exhibit biological activity. Significant focus has been given to the development of synthetic approaches for the preparation of triazoles, and they are today easily obtainable through a large variety of protocols. The number of synthetic procedures for the formation of triazolines, on the other hand, is limited and further research in this field is required. The protocol presented here gives access to a broad scope of 1,4,5-substituted 1,2,3-triazolines through a one-pot transformation of carboxamides. The two-step procedure involves a Mo(CO)6-catalyzed reduction of tertiary amides to afford the corresponding enamines, followed by in situ cycloaddition of organic azides to form triazolines. The amide reduction is chemoselective and allows for a wide variety of functional groups such as esters, ketones, aldehydes, and imines to be tolerated. Furthermore, a modification of this one-pot procedure gives access to the corresponding triazoles. The chemically stable amide functionality is demonstrated to be an efficient synthetic handle for the formation of highly substituted triazolines or triazoles.