4985-85-7

Basic information

• Product Name: N-(3-AMINOPROPYL)DIETHANOLAMINE
• Synonyms: 2,2’-[(3-aminopropyl)imino]bis-ethano;Aminopropyldiethanolamine;Ethanol, 2,2'-((3-aminopropyl)imino)di-;Ethanol, 2,2'-(aminopropylimino)-;Ethanol, 2,2'-[(3-aminopropyl)imino]bis-;N,N-Bis(hydroxyethyl)-1,3-propanediamine;N,N-Di(2-hydroxyethyl)-1,3-propanediamine;2-[(3-AMINO-PROPYL)-(2-HYDROXY-ETHYL)-AMINO]-ETHANOL
• CAS NO: 4985-85-7
• Molecular Formula: C₇H₁₈N₂O₂
• Molecular Weight: 162.23
• EINECS: 225-642-0
• Mol File: 4985-85-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 207 °C
• Flash Point: 138°C
• Appearance: colorless liquid with a faint fishlike odor
• Density: 1,07 g/cm3
• Vapor Pressure: 3.45E-05mmHg at 25°C
• Refractive Index: 1.4985 (589.3 nm 27℃)
• Solubility: Soluble in water
• PKA: 14.40±0.10(Predicted)
• Water Solubility: 10g/L at 20℃
• CAS DataBase Reference: N-(3-AMINOPROPYL)DIETHANOLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-AMINOPROPYL)DIETHANOLAMINE(4985-85-7)
• EPA Substance Registry System: N-(3-AMINOPROPYL)DIETHANOLAMINE(4985-85-7)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 4985-85-7(Hazardous Substances Data)

Usage

Uses

N-(3-Aminopropyl)diethanolamine acts as a potential coreactant for enhancing tris(2,2’-bipyridyl)ruthenium(II) electrochemiluminescence.

General Description

A colorless liquid with a faint fishlike odor. May burn though N-(3-AMINOPROPYL)DIETHANOLAMINE may require some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-(3-AMINOPROPYL)DIETHANOLAMINE is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C7H18N2O2/c8-2-1-3-9(4-6-10)5-7-11/h10-11H,1-8H2/p+2

Upstream product

• 17209-72-2 3-[bis(2-hydroxyethyl)amino]propionitrile 
• 64-17-5 ethanol 
• 118811-21-5 N-(3-phthalimidopropyl)diethanolamine 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 111-42-2 2,2'-iminobis[ethanol] 

Downstream Products

• 103650-17-5 N,N-bis-(2-hydroxy-ethyl)-N'-(2-phenyl-[4]quinolyl)-propanediyldiamine 
• 646506-23-2 C₅₄H₇₅N₆O₁₅PSi 
• 646506-09-4 C₅₄H₇₅N₆O₁₅PSi 
• 1117726-59-6 C₁₀₄H₁₅₅N₁₁O₁₃ 
• 1117726-58-5 C₄₄H₇₂N₄O₆ 
• 37515-07-4 n,n-bis(3,4-Dihexoxybenzyl)-N',N'-Bis(2-Hydroxyethyl)-1,3-Propanediamine 
• 35607-20-6 N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)1,3-propanediamine 
• 651734-32-6 7-{3-[Bis-(2-hydroxy-ethyl)-amino]-propylamino}-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-1-ethyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one 
• 17671-49-7 N,N,N'-tris-(2-hydroxyethyl)-N'-octadecyl-1,3-diaminopropane 
• 103640-84-2 N,N-bis-(2-chloro-ethyl)-N'-(2-phenyl-[4]quinolyl)-propanediyldiamine; dihydrochloride 
• 646506-11-8 C₆₈H₈₃N₆O₁₇PSi 
• 646506-25-4 C₆₈H₈₃N₆O₁₇PSi 

Relevant articles and documents

Cobalt complexation with unsymmetrical tripodal ligands

The reaction of the aliphatic unsymmetrical tripod [N(CH2CH 2NH2)2(CH2CH2OH)], H 5-1, with cobalt(II) chloride in THF yields after aerial oxidation the dinuclear complex [(H4-1)CoIII(μ-OH)Co III(H4-1)](CoIICl4)Cl, [5](CoCl 4)Cl. The trianion 53- contains two cobalt atoms triply bridged by two alkoxo groups of the singly deprotonated ligand (H 4-1)- and a hydroxo group. The new ligand [N(CH 2CH2CH2NH2)(CH2CH 2OH)2], H4-3, providing an N2O 2 donor set reacts with cobalt(II) chloride to give after aerial oxidation the hexanuclear complex [CoIII4(H 2-3)4CoII2(HOMe)2Cl 2(μ-OH)4], [6]Cl2, containing an unprecedented mixed-valent CoIII4CoII 2 core.

Synthesis and DNA-Sequence Selectivity of a Series of Mono- and Difunctional 9-Aminoacridine Nitrogen Mustards

The aim of this work was to identify nitrogen mustards that would react selectively with DNA, particularly in G-rich regions.A series of mono- and difunctional nitrogen mustards was synthesized in which the (2-chloroethyl)amino functions were connected to the N9 of 9-aminoacridine by way of a spacer chain consisting of two to six methylene units.The length of the spacer chain connecting the alkylating and putative DNA-intercalating groups was found to affect the preference for the alkylation of different guanine-N7 positions in a DNA sequence.All of the compounds reacted preferentially at G's that are followed by G as do most other types of nitrogen mustards, but the degree of selectivity was greater.The compounds reacted at much lower concentrations than were required for comparable reaction by mechlorethamine (HN2), consistent with initial noncovalent binding to DNA prior to guanine-N7 alkylation.The degree of DNA-sequance selectivity increased as the spacer-chain length decrease below four methylene units.Most strikingly, long spacer compounds reacted strongly at 5'-GT-3' sequences, whereas this reaction was almost completely suppressed when the spacer length was reduced to two or three methylenes.Mono- and difunctional compounds of a given spacer length showed no consistent difference in DNA-sequence preference.